Post-DAE: Anatomically Plausible Segmentation via Post-Processing with Denoising Autoencoders

We introduce Post-DAE, a post-processing method based on denoising autoencoders (DAE) to improve the anatomical plausibility of arbitrary biomedical image segmentation algorithms. Some of the most popular segmentation methods (e.g. based on convolutional neural networks or random forest classifiers) incorporate additional post-processing steps to ensure that the resulting masks fulfill expected connectivity constraints. These methods operate under the hypothesis that contiguous pixels with similar aspect should belong to the same class. Even if valid in general, this assumption does not consider more complex priors like topological restrictions or convexity, which cannot be easily incorporated into these methods. Post-DAE leverages the latest developments in manifold learning via denoising autoencoders. First, we learn a compact and non-linear embedding that represents the space of anatomically plausible segmentations. Then, given a segmentation mask obtained with an arbitrary method, we reconstruct its anatomically plausible version by projecting it onto the learnt manifold. The proposed method is trained using unpaired segmentation mask, what makes it independent of intensity information and image modality. We performed experiments in binary and multi-label segmentation of chest X-ray and cardiac magnetic resonance images. We show how erroneous and noisy segmentation masks can be improved using Post-DAE. With almost no additional computation cost, our method brings erroneous segmentations back to a feasible space.

Learning Deformable Registration of Medical Images with Anatomical Constraints

Deformable image registration is a fundamental problem in the field of medical image analysis. During the last years, we have witnessed the advent of deep learning-based image registration methods which achieve state-of-the-art performance, and drastically reduce the required computational time. However, little work has been done regarding how can we encourage our models to produce not only accurate, but also anatomically plausible results, which is still an open question in the field. In this work, we argue that incorporating anatomical priors in the form of global constraints into the learning process of these models, will further improve their performance and boost the realism of the warped images after registration. We learn global non-linear representations of image anatomy using segmentation masks, and employ them to constraint the registration process. The proposed AC-RegNet architecture is evaluated in the context of chest X-ray image registration using three different datasets, where the high anatomical variability makes the task extremely challenging. Our experiments show that the proposed anatomically constrained registration model produces more realistic and accurate results than state-of-the-art methods, demonstrating the potential of this approach.

Anatomical Priors for Image Segmentation via Post-Processing with Denoising Autoencoders

Deep convolutional neural networks (CNN) proved to be highly accurate to perform anatomical segmentation of medical images. However, some of the most popular CNN architectures for image segmentation still rely on post-processing strategies (e.g. Conditional Random Fields) to incorporate connectivity constraints into the resulting masks. These post-processing steps are based on the assumption that objects are usually continuous and therefore nearby pixels should be assigned the same object label. Even if it is a valid assumption in general, these methods do not offer a straightforward way to incorporate more complex priors like convexity or arbitrary shape restrictions. In this work we propose Post-DAE, a post-processing method based on denoising autoencoders (DAE) trained using only segmentation masks. We learn a low-dimensional space of anatomically plausible segmentations, and use it as a post-processing step to impose shape constraints on the resulting masks obtained with arbitrary segmentation methods. Our approach is independent of image modality and intensity information since it employs only segmentation masks for training. This enables the use of anatomical segmentations that do not need to be paired with intensity images, making the approach very flexible. Our experimental results on anatomical segmentation of X-ray images show that Post-DAE can improve the quality of noisy and incorrect segmentation masks obtained with a variety of standard methods, by bringing them back to a feasible space, with almost no extra computational time.

Joint Learning of Brain Lesion and Anatomy Segmentation from Heterogeneous Datasets

Brain lesion and anatomy segmentation in magnetic resonance images are fundamental tasks in neuroimaging research and clinical practice. Given enough training data, convolutional neuronal networks (CNN) proved to outperform all existent techniques in both tasks independently. However, to date, little work has been done regarding simultaneous learning of brain lesion and anatomy segmentation from disjoint datasets. In this work we focus on training a single CNN model to predict brain tissue and lesion segmentations using heterogeneous datasets labeled independently, according to only one of these tasks (a common scenario when using publicly available datasets). We show that label contradiction issues can arise in this case, and propose a novel adaptive cross entropy (ACE) loss function that makes such training possible. We provide quantitative evaluation in two different scenarios, benchmarking the proposed method in comparison with a multi-network approach. Our experiments suggest that ACE loss enables training of single models when standard cross entropy and Dice loss functions tend to fail. Moreover, we show that it is possible to achieve competitive results when comparing with multiple networks trained for independent tasks.

Weakly-Supervised Learning of Metric Aggregations for Deformable Image Registration

Deformable registration has been one of the pillars of biomedical image computing. Conventional approaches refer to the definition of a similarity criterion that, once endowed with a deformation model and a smoothness constraint, determines the optimal transformation to align two given images. The definition of this metric function is among the most critical aspects of the registration process. We argue that incorporating semantic information (in the form of anatomical segmentation maps) into the registration process will further improve the accuracy of the results. In this paper, we propose a novel weakly supervised approach to learn domain specific aggregations of conventional metrics using anatomical segmentations. This combination is learned using latent structured support vector machines (LSSVM). The learned matching criterion is integrated within a metric free optimization framework based on graphical models, resulting in a multi-metric algorithm endowed with a spatially varying similarity metric function conditioned on the anatomical structures. We provide extensive evaluation on three different datasets of CT and MRI images, showing that learned multi-metric registration outperforms single-metric approaches based on conventional similarity measures.

Left ventricle quantification through spatio-temporal CNNs

Cardiovascular diseases are among the leading causes of death globally. Cardiac left ventricle (LV) quantification is known to be one of the most important tasks for the identification and diagnosis of such pathologies. In this paper, we propose a deep learning method that incorporates 3D spatio-temporal convolutions to perform direct left ventricle quantification from cardiac MR sequences. Instead of analysing slices independently, we process stacks of temporally adjacent slices by means of 3D convolutional kernels which fuse the spatio-temporal information, incorporating the temporal dynamics of the heart to the learned model. We show that incorporating such information by means of spatio-temporal convolutions into standard LV quantification architectures improves the accuracy of the predictions when compared with single-slice models, achieving competitive results for all cardiac indices and significantly breaking the state of the art (Xue et al., 2018, MedIA) for cardiac phase estimation.

Disease Prediction using Graph Convolutional Networks: Application to Autism Spectrum Disorder and Alzheimer's Disease

Graphs are widely used as a natural framework that captures interactions between individual elements represented as nodes in a graph. In medical applications, specifically, nodes can represent individuals within a potentially large population (patients or healthy controls) accompanied by a set of features, while the graph edges incorporate associations between subjects in an intuitive manner. This representation allows to incorporate the wealth of imaging and non-imaging information as well as individual subject features simultaneously in disease classification tasks. Previous graph-based approaches for supervised or unsupervised learning in the context of disease prediction solely focus on pairwise similarities between subjects, disregarding individual characteristics and features, or rather rely on subject-specific imaging feature vectors and fail to model interactions between them. In this paper, we present a thorough evaluation of a generic framework that leverages both imaging and non-imaging information and can be used for brain analysis in large populations. This framework exploits Graph Convolutional Networks (GCNs) and involves representing populations as a sparse graph, where its nodes are associated with imaging-based feature vectors, while phenotypic information is integrated as edge weights. The extensive evaluation explores the effect of each individual component of this framework on disease prediction performance and further compares it to different baselines. The framework performance is tested on two large datasets with diverse underlying data, ABIDE and ADNI, for the prediction of Autism Spectrum Disorder and conversion to Alzheimer's disease, respectively. Our analysis shows that our novel framework can improve over state-of-the-art results on both databases, with 70.4% classification accuracy for ABIDE and 80.0% for ADNI.

Anatomically Constrained Neural Networks (ACNN): Application to Cardiac Image Enhancement and Segmentation

Incorporation of prior knowledge about organ shape and location is key to improve performance of image analysis approaches. In particular, priors can be useful in cases where images are corrupted and contain artefacts due to limitations in image acquisition. The highly constrained nature of anatomical objects can be well captured with learning based techniques. However, in most recent and promising techniques such as CNN based segmentation it is not obvious how to incorporate such prior knowledge. State-of-the-art methods operate as pixel-wise classifiers where the training objectives do not incorporate the structure and inter-dependencies of the output. To overcome this limitation, we propose a generic training strategy that incorporates anatomical prior knowledge into CNNs through a new regularisation model, which is trained end-to-end. The new framework encourages models to follow the global anatomical properties of the underlying anatomy (e.g. shape, label structure) via learned non-linear representations of the shape. We show that the proposed approach can be easily adapted to different analysis tasks (e.g. image enhancement, segmentation) and improve the prediction accuracy of the state-of-the-art models. The applicability of our approach is shown on multi-modal cardiac datasets and public benchmarks. Additionally, we demonstrate how the learned deep models of 3D shapes can be interpreted and used as biomarkers for classification of cardiac pathologies.

Ensembles of Multiple Models and Architectures for Robust Brain Tumour Segmentation

Deep learning approaches such as convolutional neural nets have consistently outperformed previous methods on challenging tasks such as dense, semantic segmentation. However, the various proposed networks perform differently, with behaviour largely influenced by architectural choices and training settings. This paper explores Ensembles of Multiple Models and Architectures (EMMA) for robust performance through aggregation of predictions from a wide range of methods. The approach reduces the influence of the meta-parameters of individual models and the risk of overfitting the configuration to a particular database. EMMA can be seen as an unbiased, generic deep learning model which is shown to yield excellent performance, winning the first position in the BRATS 2017 competition among 50+ participating teams.