Kartezio: Evolutionary Design of Explainable Pipelines for Biomedical Image Analysis

An unresolved issue in contemporary biomedicine is the overwhelming number and diversity of complex images that require annotation, analysis and interpretation. Recent advances in Deep Learning have revolutionized the field of computer vision, creating algorithms that compete with human experts in image segmentation tasks. Crucially however, these frameworks require large human-annotated datasets for training and the resulting models are difficult to interpret. In this study, we introduce Kartezio, a modular Cartesian Genetic Programming based computational strategy that generates transparent and easily interpretable image processing pipelines by iteratively assembling and parameterizing computer vision functions. The pipelines thus generated exhibit comparable precision to state-of-the-art Deep Learning approaches on instance segmentation tasks, while requiring drastically smaller training datasets, a feature which confers tremendous flexibility, speed, and functionality to this approach. We also deployed Kartezio to solve semantic and instance segmentation problems in four real-world Use Cases, and showcase its utility in imaging contexts ranging from high-resolution microscopy to clinical pathology. By successfully implementing Kartezio on a portfolio of images ranging from subcellular structures to tumoral tissue, we demonstrated the flexibility, robustness and practical utility of this fully explicable evolutionary designer for semantic and instance segmentation.

Curiosity creates Diversity in Policy Search

When searching for policies, reward-sparse environments often lack sufficient information about which behaviors to improve upon or avoid. In such environments, the policy search process is bound to blindly search for reward-yielding transitions and no early reward can bias this search in one direction or another. A way to overcome this is to use intrinsic motivation in order to explore new transitions until a reward is found. In this work, we use a recently proposed definition of intrinsic motivation, Curiosity, in an evolutionary policy search method. We propose Curiosity-ES, an evolutionary strategy adapted to use Curiosity as a fitness metric. We compare Curiosity with Novelty, a commonly used diversity metric, and find that Curiosity can generate higher diversity over full episodes without the need for an explicit diversity criterion and lead to multiple policies which find reward.

Architectural Optimization over Subgroups for Equivariant Neural Networks

Incorporating equivariance to symmetry groups as a constraint during neural network training can improve performance and generalization for tasks exhibiting those symmetries, but such symmetries are often not perfectly nor explicitly present. This motivates algorithmically optimizing the architectural constraints imposed by equivariance. We propose the equivariance relaxation morphism, which preserves functionality while reparameterizing a group equivariant layer to operate with equivariance constraints on a subgroup, as well as the $[G]$-mixed equivariant layer, which mixes layers constrained to different groups to enable within-layer equivariance optimization. We further present evolutionary and differentiable neural architecture search (NAS) algorithms that utilize these mechanisms respectively for equivariance-aware architectural optimization. Experiments across a variety of datasets show the benefit of dynamically constrained equivariance to find effective architectures with approximate equivariance.

On Neural Consolidation for Transfer in Reinforcement Learning

Although transfer learning is considered to be a milestone in deep reinforcement learning, the mechanisms behind it are still poorly understood. In particular, predicting if knowledge can be transferred between two given tasks is still an unresolved problem. In this work, we explore the use of network distillation as a feature extraction method to better understand the context in which transfer can occur. Notably, we show that distillation does not prevent knowledge transfer, including when transferring from multiple tasks to a new one, and we compare these results with transfer without prior distillation. We focus our work on the Atari benchmark due to the variability between different games, but also to their similarities in terms of visual features.

Neural Distillation as a State Representation Bottleneck in Reinforcement Learning

Learning a good state representation is a critical skill when dealing with multiple tasks in Reinforcement Learning as it allows for transfer and better generalization between tasks. However, defining what constitute a useful representation is far from simple and there is so far no standard method to find such an encoding. In this paper, we argue that distillation -- a process that aims at imitating a set of given policies with a single neural network -- can be used to learn a state representation displaying favorable characteristics. In this regard, we define three criteria that measure desirable features of a state encoding: the ability to select important variables in the input space, the ability to efficiently separate states according to their corresponding optimal action, and the robustness of the state encoding on new tasks. We first evaluate these criteria and verify the contribution of distillation on state representation on a toy environment based on the standard inverted pendulum problem, before extending our analysis on more complex visual tasks from the Atari and Procgen benchmarks.

When, where, and how to add new neurons to ANNs

Neurogenesis in ANNs is an understudied and difficult problem, even compared to other forms of structural learning like pruning. By decomposing it into triggers and initializations, we introduce a framework for studying the various facets of neurogenesis: when, where, and how to add neurons during the learning process. We present the Neural Orthogonality (NORTH*) suite of neurogenesis strategies, combining layer-wise triggers and initializations based on the orthogonality of activations or weights to dynamically grow performant networks that converge to an efficient size. We evaluate our contributions against other recent neurogenesis works with MLPs.

On Constrained Optimization in Differentiable Neural Architecture Search

Differentiable Architecture Search (DARTS) is a recently proposed neural architecture search (NAS) method based on a differentiable relaxation. Due to its success, numerous variants analyzing and improving parts of the DARTS framework have recently been proposed. By considering the problem as a constrained bilevel optimization, we propose and analyze three improvements to architectural weight competition, update scheduling, and regularization towards discretization. First, we introduce a new approach to the activation of architecture weights, which prevents confounding competition within an edge and allows for fair comparison across edges to aid in discretization. Next, we propose a dynamic schedule based on per-minibatch network information to make architecture updates more informed. Finally, we consider two regularizations, based on proximity to discretization and the Alternating Directions Method of Multipliers (ADMM) algorithm, to promote early discretization. Our results show that this new activation scheme reduces final architecture size and the regularizations improve reliability in search results while maintaining comparable performance to state-of-the-art in NAS, especially when used with our new dynamic informed schedule.