Advancing Text-Driven Chest X-Ray Generation with Policy-Based Reinforcement Learning

Recent advances in text-conditioned image generation diffusion models have begun paving the way for new opportunities in modern medical domain, in particular, generating Chest X-rays (CXRs) from diagnostic reports. Nonetheless, to further drive the diffusion models to generate CXRs that faithfully reflect the complexity and diversity of real data, it has become evident that a nontrivial learning approach is needed. In light of this, we propose CXRL, a framework motivated by the potential of reinforcement learning (RL). Specifically, we integrate a policy gradient RL approach with well-designed multiple distinctive CXR-domain specific reward models. This approach guides the diffusion denoising trajectory, achieving precise CXR posture and pathological details. Here, considering the complex medical image environment, we present "RL with Comparative Feedback" (RLCF) for the reward mechanism, a human-like comparative evaluation that is known to be more effective and reliable in complex scenarios compared to direct evaluation. Our CXRL framework includes jointly optimizing learnable adaptive condition embeddings (ACE) and the image generator, enabling the model to produce more accurate and higher perceptual CXR quality. Our extensive evaluation of the MIMIC-CXR-JPG dataset demonstrates the effectiveness of our RL-based tuning approach. Consequently, our CXRL generates pathologically realistic CXRs, establishing a new standard for generating CXRs with high fidelity to real-world clinical scenarios.

EAGLE: Eigen Aggregation Learning for Object-Centric Unsupervised Semantic Segmentation

Semantic segmentation has innately relied on extensive pixel-level labeled annotated data, leading to the emergence of unsupervised methodologies. Among them, leveraging self-supervised Vision Transformers for unsupervised semantic segmentation (USS) has been making steady progress with expressive deep features. Yet, for semantically segmenting images with complex objects, a predominant challenge remains: the lack of explicit object-level semantic encoding in patch-level features. This technical limitation often leads to inadequate segmentation of complex objects with diverse structures. To address this gap, we present a novel approach, EAGLE, which emphasizes object-centric representation learning for unsupervised semantic segmentation. Specifically, we introduce EiCue, a spectral technique providing semantic and structural cues through an eigenbasis derived from the semantic similarity matrix of deep image features and color affinity from an image. Further, by incorporating our object-centric contrastive loss with EiCue, we guide our model to learn object-level representations with intra- and inter-image object-feature consistency, thereby enhancing semantic accuracy. Extensive experiments on COCO-Stuff, Cityscapes, and Potsdam-3 datasets demonstrate the state-of-the-art USS results of EAGLE with accurate and consistent semantic segmentation across complex scenes.