Federated Learning Enables Big Data for Rare Cancer Boundary Detection

Although machine learning (ML) has shown promise in numerous domains, there are concerns about generalizability to out-of-sample data. This is currently addressed by centrally sharing ample, and importantly diverse, data from multiple sites. However, such centralization is challenging to scale (or even not feasible) due to various limitations. Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here we present findings from the largest FL study to-date, involving data from 71 healthcare institutions across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, utilizing the largest dataset of such patients ever used in the literature (25,256 MRI scans from 6,314 patients). We demonstrate a 33% improvement over a publicly trained model to delineate the surgically targetable tumor, and 23% improvement over the tumor's entire extent. We anticipate our study to: 1) enable more studies in healthcare informed by large and diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further quantitative analyses for glioblastoma via performance optimization of our consensus model for eventual public release, and 3) demonstrate the effectiveness of FL at such scale and task complexity as a paradigm shift for multi-site collaborations, alleviating the need for data sharing.

A Combinatorial Optimisation Approach to Designing Dual-Parented Long-Reach Passive Optical Networks

We present an application focused on the design of resilient long-reach passive optical networks. We specifically consider dual-parented networks whereby each customer must be connected to two metro sites via local exchange sites. An important property of such a placement is resilience to single metro node failure. The objective of the application is to determine the optimal position of a set of metro nodes such that the total optical fibre length is minimized. We prove that this problem is NP-Complete. We present two alternative combinatorial optimisation approaches to finding an optimal metro node placement using: a mixed integer linear programming (MIP) formulation of the problem; and, a hybrid approach that uses clustering as a preprocessing step. We consider a detailed case-study based on a network for Ireland. The hybrid approach scales well and finds solutions that are close to optimal, with a runtime that is two orders-of-magnitude better than the MIP model.