MIRAM: Masked Image Reconstruction Across Multiple Scales for Breast Lesion Risk Prediction

Self-supervised learning (SSL) has garnered substantial interest within the machine learning and computer vision communities. Two prominent approaches in SSL include contrastive-based learning and self-distillation utilizing cropping augmentation. Lately, masked image modeling (MIM) has emerged as a more potent SSL technique, employing image inpainting as a pretext task. MIM creates a strong inductive bias toward meaningful spatial and semantic understanding. This has opened up new opportunities for SSL to contribute not only to classification tasks but also to more complex applications like object detection and image segmentation. Building upon this progress, our research paper introduces a scalable and practical SSL approach centered around more challenging pretext tasks that facilitate the acquisition of robust features. Specifically, we leverage multi-scale image reconstruction from randomly masked input images as the foundation for feature learning. Our hypothesis posits that reconstructing high-resolution images enables the model to attend to finer spatial details, particularly beneficial for discerning subtle intricacies within medical images. The proposed SSL features help improve classification performance on the Curated Breast Imaging Subset of Digital Database for Screening Mammography (CBIS-DDSM) dataset. In pathology classification, our method demonstrates a 3\% increase in average precision (AP) and a 1\% increase in the area under the receiver operating characteristic curve (AUC) when compared to state-of-the-art (SOTA) algorithms. Moreover, in mass margins classification, our approach achieves a 4\% increase in AP and a 2\% increase in AUC.

Revisiting Invariant Learning for Out-of-Domain Generalization on Multi-Site Mammogram Datasets

Despite significant progress in robust deep learning techniques for mammogram breast cancer classification, their reliability in real-world clinical development settings remains uncertain. The translation of these models to clinical practice faces challenges due to variations in medical centers, imaging protocols, and patient populations. To enhance their robustness, invariant learning methods have been proposed, prioritizing causal factors over misleading features. However, their effectiveness in clinical development and impact on mammogram classification require investigation. This paper reassesses the application of invariant learning for breast cancer risk estimation based on mammograms. Utilizing diverse multi-site public datasets, it represents the first study in this area. The objective is to evaluate invariant learning's benefits in developing robust models. Invariant learning methods, including Invariant Risk Minimization and Variance Risk Extrapolation, are compared quantitatively against Empirical Risk Minimization. Evaluation metrics include accuracy, average precision, and area under the curve. Additionally, interpretability is examined through class activation maps and visualization of learned representations. This research examines the advantages, limitations, and challenges of invariant learning for mammogram classification, guiding future studies to develop generalized methods for breast cancer prediction on whole mammograms in out-of-domain scenarios.