Automatic Diagnosis of Schizophrenia and Attention Deficit Hyperactivity Disorder in rs-fMRI Modality using Convolutional Autoencoder Model and Interval Type-2 Fuzzy Regression

Nowadays, many people worldwide suffer from brain disorders, and their health is in danger. So far, numerous methods have been proposed for the diagnosis of Schizophrenia (SZ) and attention deficit hyperactivity disorder (ADHD), among which functional magnetic resonance imaging (fMRI) modalities are known as a popular method among physicians. This paper presents an SZ and ADHD intelligent detection method of resting-state fMRI (rs-fMRI) modality using a new deep learning (DL) method. The University of California Los Angeles (UCLA) dataset, which contains the rs-fMRI modalities of SZ and ADHD patients, has been used for experiments. The FMRIB software library (FSL) toolbox first performed preprocessing on rs-fMRI data. Then, a convolutional Autoencoder (CNN-AE) model with the proposed number of layers is used to extract features from rs-fMRI data. In the classification step, a new fuzzy method called interval type-2 fuzzy regression (IT2FR) is introduced and then optimized by genetic algorithm (GA), particle swarm optimization (PSO), and gray wolf optimization (GWO) techniques. Also, the results of IT2FR methods are compared with multilayer perceptron (MLP), k-nearest neighbors (KNN), support vector machine (SVM), random forest (RF), decision tree (DT), and adaptive neuro-fuzzy inference system (ANFIS) methods. The experiment results show that the IT2FR method with the GWO optimization algorithm has achieved satisfactory results compared to other classifier methods. Finally, the proposed classification technique was able to provide 72.71% accuracy.

Accurate Prediction Using Triangular Type-2 Fuzzy Linear Regression

Many works have been done to handle the uncertainties in the data using type 1 fuzzy regression. Few type 2 fuzzy regression works used interval type 2 for indeterminate modeling using type 1 fuzzy membership. The current survey proposes a triangular type-2 fuzzy regression (TT2FR) model to ameliorate the efficiency of the model by handling the uncertainty in the data. The triangular secondary membership function is used instead of widely used interval type models. In the proposed model, vagueness in primary and secondary fuzzy sets is minimized and also, a specified x-plane of observed value is included in the same {\alpha}- plane of the predicted value. Complex calculations of the type-2 fuzzy (T2F) model are simplified by reducing three dimensional type-2 fuzzy set (3DT2FS) into two dimensional interval type-2 fuzzy (2DIT2F) models. The current survey presents a new regression model of T2F by considering the more general form of T2F membership functions and thus avoids high complexity. The performance of the developed model is evaluated using the TAIEX and COVID-19 forecasting datasets. Our developed model reached the highest performance as compared to the other state-of-art techniques. Our developed method is ready to be tested with more uncertain data and has the potential to use to predict the weather and stock prediction.

Detection of Epileptic Seizures on EEG Signals Using ANFIS Classifier, Autoencoders and Fuzzy Entropies

Epilepsy is one of the most crucial neurological disorders, and its early diagnosis will help the clinicians to provide accurate treatment for the patients. The electroencephalogram (EEG) signals are widely used for epileptic seizures detection, which provides specialists with substantial information about the functioning of the brain. In this paper, a novel diagnostic procedure using fuzzy theory and deep learning techniques are introduced. The proposed method is evaluated on the Bonn University dataset with six classification combinations and also on the Freiburg dataset. The tunable-Q wavelet transform (TQWT) is employed to decompose the EEG signals into different sub-bands. In the feature extraction step, 13 different fuzzy entropies are calculated from different sub-bands of TQWT, and their computational complexities are calculated to help researchers choose the best feature sets. In the following, an autoencoder (AE) with six layers is employed for dimensionality reduction. Finally, the standard adaptive neuro-fuzzy inference system (ANFIS), and also its variants with grasshopper optimization algorithm (ANFIS-GOA), particle swarm optimization (ANFIS-PSO), and breeding swarm optimization (ANFIS-BS) methods are used for classification. Using our proposed method, ANFIS-BS method has obtained an accuracy of 99.74% in classifying into two classes and an accuracy of 99.46% in ternary classification on the Bonn dataset and 99.28% on the Freiburg dataset, reaching state-of-the-art performances on both of them.

Applications of Epileptic Seizures Detection in Neuroimaging Modalities Using Deep Learning Techniques: Methods, Challenges, and Future Works

Epileptic seizures are a type of neurological disorder that affect many people worldwide. Specialist physicians and neurologists take advantage of structural and functional neuroimaging modalities to diagnose various types of epileptic seizures. Neuroimaging modalities assist specialist physicians considerably in analyzing brain tissue and the changes made in it. One method to accelerate the accurate and fast diagnosis of epileptic seizures is to employ computer aided diagnosis systems (CADS) based on artificial intelligence (AI) and functional and structural neuroimaging modalities. AI encompasses a variety of areas, and one of its branches is deep learning (DL). Not long ago, and before the rise of DL algorithms, feature extraction was an essential part of every conventional machine learning method, yet handcrafting features limit these models' performances to the knowledge of system designers. DL methods resolved this issue entirely by automating the feature extraction and classification process; applications of these methods in many fields of medicine, such as the diagnosis of epileptic seizures, have made notable improvements. In this paper, a comprehensive overview of the types of DL methods exploited to diagnose epileptic seizures from various neuroimaging modalities has been studied. Additionally, rehabilitation systems and cloud computing in epileptic seizures diagnosis applications have been exactly investigated using various modalities.

Automatic Diagnosis of COVID-19 from CT Images using CycleGAN and Transfer Learning

The outbreak of the corona virus disease (COVID-19) has changed the lives of most people on Earth. Given the high prevalence of this disease, its correct diagnosis in order to quarantine patients is of the utmost importance in steps of fighting this pandemic. Among the various modalities used for diagnosis, medical imaging, especially computed tomography (CT) imaging, has been the focus of many previous studies due to its accuracy and availability. In addition, automation of diagnostic methods can be of great help to physicians. In this paper, a method based on pre-trained deep neural networks is presented, which, by taking advantage of a cyclic generative adversarial net (CycleGAN) model for data augmentation, has reached state-of-the-art performance for the task at hand, i.e., 99.60% accuracy. Also, in order to evaluate the method, a dataset containing 3163 images from 189 patients has been collected and labeled by physicians. Unlike prior datasets, normal data have been collected from people suspected of having COVID-19 disease and not from data from other diseases, and this database is made available publicly.

Fusion of convolution neural network, support vector machine and Sobel filter for accurate detection of COVID-19 patients using X-ray images

The coronavirus (COVID-19) is currently the most common contagious disease which is prevalent all over the world. The main challenge of this disease is the primary diagnosis to prevent secondary infections and its spread from one person to another. Therefore, it is essential to use an automatic diagnosis system along with clinical procedures for the rapid diagnosis of COVID-19 to prevent its spread. Artificial intelligence techniques using computed tomography (CT) images of the lungs and chest radiography have the potential to obtain high diagnostic performance for Covid-19 diagnosis. In this study, a fusion of convolutional neural network (CNN), support vector machine (SVM), and Sobel filter is proposed to detect COVID-19 using X-ray images. A new X-ray image dataset was collected and subjected to high pass filter using a Sobel filter to obtain the edges of the images. Then these images are fed to CNN deep learning model followed by SVM classifier with ten-fold cross validation strategy. This method is designed so that it can learn with not many data. Our results show that the proposed CNN-SVM with Sobel filtering (CNN-SVM+Sobel) achieved the highest classification accuracy of 99.02% in accurate detection of COVID-19. It showed that using Sobel filter can improve the performance of CNN. Unlike most of the other researches, this method does not use a pre-trained network. We have also validated our developed model using six public databases and obtained the highest performance. Hence, our developed model is ready for clinical application

Handling of uncertainty in medical data using machine learning and probability theory techniques: A review of 30 years (1991-2020)

Understanding data and reaching valid conclusions are of paramount importance in the present era of big data. Machine learning and probability theory methods have widespread application for this purpose in different fields. One critically important yet less explored aspect is how data and model uncertainties are captured and analyzed. Proper quantification of uncertainty provides valuable information for optimal decision making. This paper reviewed related studies conducted in the last 30 years (from 1991 to 2020) in handling uncertainties in medical data using probability theory and machine learning techniques. Medical data is more prone to uncertainty due to the presence of noise in the data. So, it is very important to have clean medical data without any noise to get accurate diagnosis. The sources of noise in the medical data need to be known to address this issue. Based on the medical data obtained by the physician, diagnosis of disease, and treatment plan are prescribed. Hence, the uncertainty is growing in healthcare and there is limited knowledge to address these problems. We have little knowledge about the optimal treatment methods as there are many sources of uncertainty in medical science. Our findings indicate that there are few challenges to be addressed in handling the uncertainty in medical raw data and new models. In this work, we have summarized various methods employed to overcome this problem. Nowadays, application of novel deep learning techniques to deal such uncertainties have significantly increased.

Automated Detection and Forecasting of COVID-19 using Deep Learning Techniques: A Review

Coronavirus, or COVID-19, is a hazardous disease that has endangered the health of many people around the world by directly affecting the lungs. COVID-19 is a medium-sized, coated virus with a single-stranded RNA. This virus has one of the largest RNA genomes and is approximately 120 nm. The X-Ray and computed tomography (CT) imaging modalities are widely used to obtain a fast and accurate medical diagnosis. Identifying COVID-19 from these medical images is extremely challenging as it is time-consuming, demanding, and prone to human errors. Hence, artificial intelligence (AI) methodologies can be used to obtain consistent high performance. Among the AI methodologies, deep learning (DL) networks have gained much popularity compared to traditional machine learning (ML) methods. Unlike ML techniques, all stages of feature extraction, feature selection, and classification are accomplished automatically in DL models. In this paper, a complete survey of studies on the application of DL techniques for COVID-19 diagnostic and automated segmentation of lungs is discussed, concentrating on works that used X-Ray and CT images. Additionally, a review of papers on the forecasting of coronavirus prevalence in different parts of the world with DL techniques is presented. Lastly, the challenges faced in the automated detection of COVID-19 using DL techniques and directions for future research are discussed.

Deep Learning for Neuroimaging-based Diagnosis and Rehabilitation of Autism Spectrum Disorder: A Review

Accurate diagnosis of Autism Spectrum Disorder (ASD) is essential for its management and rehabilitation. Neuroimaging techniques that are non-invasive are disease markers and may be leveraged to aid ASD diagnosis. Structural and functional neuroimaging techniques provide physicians substantial information about the structure (anatomy and structural connectivity) and function (activity and functional connectivity) of the brain. Due to the intricate structure and function of the brain, diagnosing ASD with neuroimaging data without exploiting artificial intelligence (AI) techniques is extremely challenging. AI techniques comprise traditional machine learning (ML) approaches and deep learning (DL) techniques. Conventional ML methods employ various feature extraction and classification techniques, but in DL, the process of feature extraction and classification is accomplished intelligently and integrally. In this paper, studies conducted with the aid of DL networks to distinguish ASD were investigated. Rehabilitation tools provided by supporting ASD patients utilizing DL networks were also assessed. Finally, we presented important challenges in this automated detection and rehabilitation of ASD.