Classification of White Blood Cells Using Machine and Deep Learning Models: A Systematic Review

Machine learning (ML) and deep learning (DL) models have been employed to significantly improve analyses of medical imagery, with these approaches used to enhance the accuracy of prediction and classification. Model predictions and classifications assist diagnoses of various cancers and tumors. This review presents an in-depth analysis of modern techniques applied within the domain of medical image analysis for white blood cell classification. The methodologies that use blood smear images, magnetic resonance imaging (MRI), X-rays, and similar medical imaging domains are identified and discussed, with a detailed analysis of ML/DL techniques applied to the classification of white blood cells (WBCs) representing the primary focus of the review. The data utilized in this research has been extracted from a collection of 136 primary papers that were published between the years 2006 and 2023. The most widely used techniques and best-performing white blood cell classification methods are identified. While the use of ML and DL for white blood cell classification has concurrently increased and improved in recent year, significant challenges remain - 1) Availability of appropriate datasets remain the primary challenge, and may be resolved using data augmentation techniques. 2) Medical training of researchers is recommended to improve current understanding of white blood cell structure and subsequent selection of appropriate classification models. 3) Advanced DL networks including Generative Adversarial Networks, R-CNN, Fast R-CNN, and faster R-CNN will likely be increasingly employed to supplement or replace current techniques.

A Review on Classification of White Blood Cells Using Machine Learning Models

The machine learning (ML) and deep learning (DL) models contribute to exceptional medical image analysis improvement. The models enhance the prediction and improve the accuracy by prediction and classification. It helps the hematologist to diagnose the blood cancer and brain tumor based on calculations and facts. This review focuses on an in-depth analysis of modern techniques applied in the domain of medical image analysis of white blood cell classification. For this review, the methodologies are discussed that have used blood smear images, magnetic resonance imaging (MRI), X-rays, and similar medical imaging domains. The main impact of this review is to present a detailed analysis of machine learning techniques applied for the classification of white blood cells (WBCs). This analysis provides valuable insight, such as the most widely used techniques and best-performing white blood cell classification methods. It was found that in recent decades researchers have been using ML and DL for white blood cell classification, but there are still some challenges. 1) Availability of the dataset is the main challenge, and it could be resolved using data augmentation techniques. 2) Medical training of researchers is recommended to help them understand the structure of white blood cells and select appropriate classification models. 3) Advanced DL networks such as Generative Adversarial Networks, R-CNN, Fast R-CNN, and faster R-CNN can also be used in future techniques.

A Hybrid VDV Model for Automatic Diagnosis of Pneumothorax using Class-Imbalanced Chest X-rays Dataset

Pneumothorax, a life threatening disease, needs to be diagnosed immediately and efficiently. The prognosis in this case is not only time consuming but also prone to human errors. So an automatic way of accurate diagnosis using chest X-rays is the utmost requirement. To-date, most of the available medical images datasets have class-imbalance issue. The main theme of this study is to solve this problem along with proposing an automated way of detecting pneumothorax. We first compare the existing approaches to tackle the class-imbalance issue and find that data-level-ensemble (i.e. ensemble of subsets of dataset) outperforms other approaches. Thus, we propose a novel framework named as VDV model, which is a complex model-level-ensemble of data-level-ensembles and uses three convolutional neural networks (CNN) including VGG16, VGG-19 and DenseNet-121 as fixed feature extractors. In each data-level-ensemble features extracted from one of the pre-defined CNN are fed to support vector machine (SVM) classifier, and output from each data-level-ensemble is calculated using voting method. Once outputs from the three data-level-ensembles with three different CNN architectures are obtained, then, again, voting method is used to calculate the final prediction. Our proposed framework is tested on SIIM ACR Pneumothorax dataset and Random Sample of NIH Chest X-ray dataset (RS-NIH). For the first dataset, 85.17% Recall with 86.0% Area under the Receiver Operating Characteristic curve (AUC) is attained. For the second dataset, 90.9% Recall with 95.0% AUC is achieved with random split of data while 85.45% recall with 77.06% AUC is obtained with patient-wise split of data. For RS-NIH, the obtained results are higher as compared to previous results from literature However, for first dataset, direct comparison cannot be made, since this dataset has not been used earlier for Pneumothorax classification.

Automatic Diagnosis of Pneumothorax from Chest Radiographs: A Systematic Literature Review

Among various medical imaging tools, chest radiographs are the most important and widely used diagnostic tool for detection of thoracic pathologies. Researches are being carried out in order to propose robust automatic diagnostic tool for detection of pathologies from chest radiographs. Artificial Intelligence techniques especially deep learning methodologies have been found to be giving promising results in automating the field of medicine. Lot of research has been done for automatic and fast detection of pneumothorax from chest radiographs while proposing several frameworks based on artificial intelligence and machine learning techniques. This study summarizes the existing literature for the automatic detection of pneumothorax from chest x-rays along with describing the available chest radiographs datasets. The comparative analysis of the literature is also provided in terms of goodness and limitations of the existing literature along with highlighting the research gaps which need to be further explored. The paper provides a brief overview of the present work for pneumothorax detection for helping the researchers in selection of optimal approach for future research.

Exploring Language-Independent Emotional Acoustic Features via Feature Selection

We propose a novel feature selection strategy to discover language-independent acoustic features that tend to be responsible for emotions regardless of languages, linguistics and other factors. Experimental results suggest that the language-independent feature subset discovered yields the performance comparable to the full feature set on various emotional speech corpora.

Emotional State Categorization from Speech: Machine vs. Human

This paper presents our investigations on emotional state categorization from speech signals with a psychologically inspired computational model against human performance under the same experimental setup. Based on psychological studies, we propose a multistage categorization strategy which allows establishing an automatic categorization model flexibly for a given emotional speech categorization task. We apply the strategy to the Serbian Emotional Speech Corpus (GEES) and the Danish Emotional Speech Corpus (DES), where human performance was reported in previous psychological studies. Our work is the first attempt to apply machine learning to the GEES corpus where the human recognition rates were only available prior to our study. Unlike the previous work on the DES corpus, our work focuses on a comparison to human performance under the same experimental settings. Our studies suggest that psychology-inspired systems yield behaviours that, to a great extent, resemble what humans perceived and their performance is close to that of humans under the same experimental setup. Furthermore, our work also uncovers some differences between machine and humans in terms of emotional state recognition from speech.