An Infectious Disease Spread Simulation Based on Large Language Model Decision Making

Modelling individual decision-making during infectious disease outbreaks is crucial for understanding behavioural dynamics and informing effective public health interventions. Prior work has shown that large language models can simulate realistic human behaviour by generating agent decisions based on demographic prompts and situational context. We build on this foundation with a spatially grounded, agent-based simulation framework that integrates LLM-generated decisions about self-reported influenza-like illness into a census-based synthetic population of agents. Location is treated as a central feature: agents are assigned to spatial units within cities, capturing the spatial distributions of different demographic groups using real-world census data and enabling geographically diverse behavioural modelling. We implement and compare three decision scenarios, independent reasoning, household influence, and message framing, and simulate self-reporting outcomes in San Francisco and Atlanta. Results reveal that income and education are the dominant drivers of reporting rate variation, with smaller but consistent effects from geography, LLM model choice, and message framing. Our framework generates synthetic data that captures both social and geographic heterogeneity, supporting spatial epidemiological modelling and bias-aware behavioural analysis.

From Points to Places: Towards Human Mobility-Driven Spatiotemporal Foundation Models via Understanding Places

Capturing human mobility is essential for modeling how people interact with and move through physical spaces, reflecting social behavior, access to resources, and dynamic spatial patterns. To support scalable and transferable analysis across diverse geographies and contexts, there is a need for a generalizable foundation model for spatiotemporal data. While foundation models have transformed language and vision, they remain limited in handling the unique challenges posed by the spatial, temporal, and semantic complexity of mobility data. This vision paper advocates for a new class of spatial foundation models that integrate geolocation semantics with human mobility across multiple scales. Central to our vision is a shift from modeling discrete points of interest to understanding places: dynamic, context-rich regions shaped by human behavior and mobility that may comprise many places of interest. We identify key gaps in adaptability, scalability, and multi-granular reasoning, and propose research directions focused on modeling places and enabling efficient learning. Our goal is to guide the development of scalable, context-aware models for next-generation geospatial intelligence. These models unlock powerful applications ranging from personalized place discovery and logistics optimization to urban planning, ultimately enabling smarter and more responsive spatial decision-making.