Six-dimensional movable antenna (6DMA) is a promising technology to fully exploit spatial variation in wireless channels by allowing flexible adjustment of three-dimensional (3D) positions and rotations of antennas at the transceiver. In this paper, we investigate the practical low-complexity design of 6DMA-enabled communication systems, including transmission protocol, statistical channel information (SCI) acquisition, and joint position and rotation optimization of 6DMA surfaces based on the SCI of users. Specifically, an orthogonal matching pursuit (OMP)-based algorithm is proposed for the estimation of SCI of users at all possible position-rotation pairs of 6DMA surfaces based on the channel measurements at a small subset of position-rotation pairs. Then, the average sum logarithmic rate of all users is maximized by jointly designing the positions and rotations of 6DMA surfaces based on their SCI acquired. Different from prior works on 6DMA which adopt alternating optimization to design 6DMA positions/rotations with iterations, we propose a new sequential optimization approach that first determines 6DMA rotations and then finds their feasible positions to realize the optimized rotations subject to practical antenna placement constraints. Simulation results show that the proposed sequential optimization significantly reduces the computational complexity of conventional alternating optimization, while achieving comparable communication performance. It is also shown that the proposed SCI-based 6DMA design can effectively enhance the communication throughput of wireless networks over existing fixed (position and rotation) antenna arrays, yet with a practically appealing low-complexity implementation.