Existing fraud detection methods predominantly rely on transcribed text, suffering from ASR errors and missing crucial acoustic cues like vocal tone and environmental context. This limits their effectiveness against complex deceptive strategies. To address these challenges, we first propose \textbf{SAFE-QAQ}, an end-to-end comprehensive framework for audio-based slow-thinking fraud detection. First, the SAFE-QAQ framework eliminates the impact of transcription errors on detection performance. Secondly, we propose rule-based slow-thinking reward mechanisms that systematically guide the system to identify fraud-indicative patterns by accurately capturing fine-grained audio details, through hierarchical reasoning processes. Besides, our framework introduces a dynamic risk assessment framework during live calls, enabling early detection and prevention of fraud. Experiments on the TeleAntiFraud-Bench demonstrate that SAFE-QAQ achieves dramatic improvements over existing methods in multiple key dimensions, including accuracy, inference efficiency, and real-time processing capabilities. Currently deployed and analyzing over 70,000 calls daily, SAFE-QAQ effectively automates complex fraud detection, reducing human workload and financial losses. Code: https://anonymous.4open.science/r/SAFE-QAQ.