Driven by scaling laws, recommender systems increasingly rely on large-scale models to capture complex feature interactions and user behaviors, but this trend also leads to prohibitive training and inference costs. While long-sequence models(e.g., LONGER) can reuse user-side computation through KV caching, such reuse is difficult in dense feature interaction architectures(e.g., RankMixer), where user and group (candidate item) features are deeply entangled across layers. In this work, we propose User-Group Separation (UG-Sep), a novel framework that enables reusable user-side computation in dense interaction models for the first time. UG-Sep introduces a masking mechanism that explicitly disentangles user-side and item-side information flows within token-mixing layers, ensuring that a subset of tokens to preserve purely user-side representations across layers. This design enables corresponding token computations to be reused across multiple samples, significantly reducing redundant inference cost. To compensate for potential expressiveness loss induced by masking, we further propose an Information Compensation strategy that adaptively reconstructs suppressed user-item interactions. Moreover, as UG-Sep substantially reduces user-side FLOPs and exposes memory-bound components, we incorporate W8A16 (8-bit weight, 16-bit activation) weight-only quantization to alleviate memory bandwidth bottlenecks and achieve additional acceleration. We conduct extensive offline evaluations and large-scale online A/B experiments at ByteDance, demonstrating that UG-Sep reduces inference latency by up to 20 percent without degrading online user experience or commercial metrics across multiple business scenarios, including feed recommendation and advertising systems.