Latent Bridge: Feature Delta Prediction for Efficient Dual-System Vision-Language-Action Model Inference

Dual-system Vision-Language-Action (VLA) models achieve state-of-the-art robotic manipulation but are bottlenecked by the VLM backbone, which must execute at every control step while producing temporally redundant features. We propose Latent Bridge, a lightweight model that predicts VLM output deltas between timesteps, enabling the action head to operate on predicted outputs while the expensive VLM backbone is called only periodically. We instantiate Latent Bridge on two architecturally distinct VLAs: GR00T-N1.6 (feature-space bridge) and π0.5 (KV-cache bridge), demonstrating that the approach generalizes across VLA designs. Our task-agnostic DAgger training pipeline transfers across benchmarks without modification. Across four LIBERO suites, 24 RoboCasa kitchen tasks, and the ALOHA sim transfer-cube task, Latent Bridge achieves 95-100% performance retention while reducing VLM calls by 50-75%, yielding 1.65-1.73x net per-episode speedup.

scDrugMap: Benchmarking Large Foundation Models for Drug Response Prediction

Drug resistance presents a major challenge in cancer therapy. Single cell profiling offers insights into cellular heterogeneity, yet the application of large-scale foundation models for predicting drug response in single cell data remains underexplored. To address this, we developed scDrugMap, an integrated framework featuring both a Python command-line interface and a web server for drug response prediction. scDrugMap evaluates a wide range of foundation models, including eight single-cell models and two large language models, using a curated dataset of over 326,000 cells in the primary collection and 18,800 cells in the validation set, spanning 36 datasets and diverse tissue and cancer types. We benchmarked model performance under pooled-data and cross-data evaluation settings, employing both layer freezing and Low-Rank Adaptation (LoRA) fine-tuning strategies. In the pooled-data scenario, scFoundation achieved the best performance, with mean F1 scores of 0.971 (layer freezing) and 0.947 (fine-tuning), outperforming the lowest-performing model by over 50%. In the cross-data setting, UCE excelled post fine-tuning (mean F1: 0.774), while scGPT led in zero-shot learning (mean F1: 0.858). Overall, scDrugMap provides the first large-scale benchmark of foundation models for drug response prediction in single-cell data and serves as a user-friendly, flexible platform for advancing drug discovery and translational research.