DeepRHP: A Hybrid Variational Autoencoder for Designing Random Heteropolymers as Protein Mimics

Synthetic random heteropolymers (RHPs), consisting of a predefined set of monomers, offer an approach toward the design of protein-like materials. These RHPs, if designed appropriately, can mimic protein behavior and function. As such, there is a need for computational tools to efficiently guide RHP design. We bridge this gap by developing DeepRHP, a modified variational autoencoder (VAE) model under a semi-supervised framework. By equipping a classical VAE with an additional feature-based VAE, DeepRHP forces the latent space to capture structures of critical chemical features as well as individual RHP sequence patterns. In this sense, our method is versatile by allowing any relevant features to be incorporated in a hybrid manner. We demonstrate the effectiveness of DeepRHP by suggesting potential monomer compositions that stabilize membrane proteins (e.g. Aquaporin Z) in non-native environments and cross-validating our prediction with published results. The concordance between our model and true RHP function suggests strong potential in utilizing hybrid autoencoder architectures to guide RHP design for proteins and other biological compounds.

DUALVISION: RGB-Infrared Multimodal Large Language Models for Robust Visual Reasoning

Multimodal large language models (MLLMs) have achieved impressive performance on visual perception and reasoning tasks with RGB imagery, yet they remain fragile under common degradations, such as fog, blur, or low-light conditions. Infrared (IR) imaging, a well-established complement to RGB, offers inherent robustness in these conditions, but its integration into MLLMs remains underexplored. To bridge this gap, we propose DUALVISION, a lightweight fusion module that efficiently incorporates IR-RGB information into MLLMs via patch-level localized cross-attention. To support training and evaluation and to facilitate future research, we also introduce DV-204K, a dataset of ~25K publicly available aligned IR-RGB image pairs with 204K modality-specific QA annotations, and DV-500, a benchmark of 500 IR-RGB image pairs with 500 QA pairs designed for evaluating cross-modal reasoning. Leveraging these datasets, we benchmark both open- and closed-source MLLMs and demonstrate that DUALVISION delivers strong empirical performance under a wide range of visual degradations. Our code and dataset are available at https://abrarmajeedi.github.io/dualvision.