Diffusion with a Linguistic Compass: Steering the Generation of Clinically Plausible Future sMRI Representations for Early MCI Conversion Prediction

Early prediction of Mild Cognitive Impairment (MCI) conversion is hampered by a trade-off between immediacy--making fast predictions from a single baseline sMRI--and accuracy--leveraging longitudinal scans to capture disease progression. We propose MCI-Diff, a diffusion-based framework that synthesizes clinically plausible future sMRI representations directly from baseline data, achieving both real-time risk assessment and high predictive performance. First, a multi-task sequence reconstruction strategy trains a shared denoising network on interpolation and extrapolation tasks to handle irregular follow-up sampling and learn robust latent trajectories. Second, an LLM-driven "linguistic compass" is introduced for clinical plausibility sampling: generated feature candidates are quantized, tokenized, and scored by a fine-tuned language model conditioned on expected structural biomarkers, guiding autoregressive generation toward realistic disease patterns. Experiments on ADNI and AIBL cohorts show that MCI-Diff outperforms state-of-the-art baselines, improving early conversion accuracy by 5-12%.

GarmentGS: Point-Cloud Guided Gaussian Splatting for High-Fidelity Non-Watertight 3D Garment Reconstruction

Traditional 3D garment creation requires extensive manual operations, resulting in time and labor costs. Recently, 3D Gaussian Splatting has achieved breakthrough progress in 3D scene reconstruction and rendering, attracting widespread attention and opening new pathways for 3D garment reconstruction. However, due to the unstructured and irregular nature of Gaussian primitives, it is difficult to reconstruct high-fidelity, non-watertight 3D garments. In this paper, we present GarmentGS, a dense point cloud-guided method that can reconstruct high-fidelity garment surfaces with high geometric accuracy and generate non-watertight, single-layer meshes. Our method introduces a fast dense point cloud reconstruction module that can complete garment point cloud reconstruction in 10 minutes, compared to traditional methods that require several hours. Furthermore, we use dense point clouds to guide the movement, flattening, and rotation of Gaussian primitives, enabling better distribution on the garment surface to achieve superior rendering effects and geometric accuracy. Through numerical and visual comparisons, our method achieves fast training and real-time rendering while maintaining competitive quality.