HGP-Mamba: Integrating Histology and Generated Protein Features for Mamba-based Multimodal Survival Risk Prediction

Recent advances in multimodal learning have significantly improved cancer survival risk prediction. However, the joint prognostic potential of protein markers and histopathology images remains underexplored, largely due to the high cost and limited availability of protein expression profiling. To address this challenge, we propose HGP-Mamba, a Mamba-based multimodal framework that efficiently integrates histological with generated protein features for survival risk prediction. Specifically, we introduce a protein feature extractor (PFE) that leverages pretrained foundation models to derive high-throughput protein embeddings directly from Whole Slide Images (WSIs), enabling data-efficient incorporation of molecular information. Together with histology embeddings that capture morphological patterns, we further introduce the Local Interaction-aware Mamba (LiAM) for fine-grained feature interaction and the Global Interaction-enhanced Mamba (GiEM) to promote holistic modality fusion at the slide level, thus capture complex cross-modal dependencies. Experiments on four public cancer datasets demonstrate that HGP-Mamba achieves state-of-the-art performance while maintaining superior computational efficiency compared with existing methods. Our source code is publicly available at <a href="https://github.com/Daijing-ai/HGP-Mamba.git">this https URL</a>.

Video2LoRA: Unified Semantic-Controlled Video Generation via Per-Reference-Video LoRA

Achieving semantic alignment across diverse video generation conditions remains a significant challenge. Methods that rely on explicit structural guidance often enforce rigid spatial constraints that limit semantic flexibility, whereas models tailored for individual control types lack interoperability and adaptability. These design bottlenecks hinder progress toward flexible and efficient semantic video generation. To address this, we propose Video2LoRA, a scalable and generalizable framework for semantic-controlled video generation that conditions on a reference video. Video2LoRA employs a lightweight hypernetwork to predict personalized LoRA weights for each semantic input, which are combined with auxiliary matrices to form adaptive LoRA modules integrated into a frozen diffusion backbone. This design enables the model to generate videos consistent with the reference semantics while preserving key style and content variations, eliminating the need for any per-condition training. Notably, the final model weights less than 150MB, making it highly efficient for storage and deployment. Video2LoRA achieves coherent, semantically aligned generation across diverse conditions and exhibits strong zero-shot generalization to unseen semantics.