From Sounds to Scenes: A Benchmark for Evaluating Context-Aware Auditory Scene Understanding in Large Audio Language Models

Recent Large Audio Language Models (LALMs) have achieved remarkable progress in audio perceptual tasks across individual acoustic layers, including speech, sound, and music. However, existing benchmarks predominantly evaluate these layers in isolation, overlooking the complex contextual relationships that arise when multiple acoustic sources co-occur in real-world auditory scenes. Real-world auditory interpretation requires Context-Aware Auditory Scene Understanding (CASU): the ability to comprehend the holistic scene by integrating sound layers. To evaluate this capability, we introduce the CASU benchmark, which assesses whether Audio LLMs can interpret auditory scenes composed of speech, acoustic events (e.g., announcements), and background environments (e.g., traffic), and reason about the logical relationships between these layers. We propose a scalable pipeline for constructing time-accurate, semi-synthetic audio streams by composing real-world scene sounds with synthetic speech. Building on this data, we design four tasks that probe scene understanding: contextual question answering, entity extraction from the scene, speaker role inference, and counterfactual reasoning where scene is manipulated. Experiments across multiple LALMs demonstrate that effective auditory scene understanding requires integration over all auditory layers, rather than reliance on speech or sound alone, underscoring the necessity of CASU for advancing complex audio understanding in LALMs.

AP-GRPO: Anchor-Gated Phonetic Alignment with Policy Optimization for Pathological Speech Reconstruction

Pathological speech from patients with neurodegenerative and neuromotor disorders is often acoustically distorted and linguistically fragmented, making pathological speech reconstruction necessary to recover intended textual content from distorted and incomplete speech recordings. Crucially, such recordings are rarely uniformly degraded: some words or short phrases remain reliable and can serve as audible anchors for reconstructing the corrupted surrounding content. We introduce Anchor-gated Phonetic Group Relative Policy Optimization (AP-GRPO), a GRPO framework with phonetic reward that aligns speech language models (SLMs) through audible-anchor preservation and inter-anchor phonetic compatibility to the original speech signal. AP-GRPO consists of: (i) an anchor-gated reward that matches reliable audible anchors in clear regions; and (ii) an inter-anchor phonetic alignment reward that evaluates whether recovered contents are phonetically supported by the corresponding corrupted inter-anchor speech span. Across four disease conditions, AP-GRPO improves faithful speech reconstruction, and the learned anchor constraint automatically adapts to each condition and thus reveals interpretable disease-specific profiles: conditions with severe articulatory degradation require stronger anchor enforcement, whereas milder impairment or linguistically impaired conditions rely more on phonetic alignment for inter-anchor recovery.

Can the Environment Speak for Itself? $T^{2}$-GRPO: A Turn-Trajectory Group Relative Policy Optimization for Caregiver Agents

Optimizing large language models (LLMs) for long-horizon caregiver agents requires balancing delayed task objectives with immediate environment dynamics, such as patient distress and resistance. In dementia care, this balance is especially difficult: trajectory level rewards are too sparse for turn level credit assignment, while external LLM-based evaluators are costly and can misread fragmented or indirect patient responses. To address this issue, we propose \textbf{T}urn-\textbf{T}rajectory \textbf{G}roup \textbf{R}elative \textbf{P}olicy \textbf{O}ptimization (\textbf{T$^{2}$-GRPO}), a framework that decouples caregiver RL into two normalized reward horizons and enforces safety through a binary hard veto. $T^2$-GRPO derives dense turn-level rewards directly from environment state transitions, measuring changes in patient distress and resistance from a frozen dementia patient simulator. These environment-grounded rewards are combined with trajectory-level evaluations through independent centered-rank normalization, which preserves heterogeneous reward signals and mitigates reward collapse. Extensive experiments on dementia caregivers show that T $^{2}$-GRPO outperforms competitive baselines, indicating a substantial improvement for emotionally sensitive caregiver scenarios that effectively handles immediate patient feedback, long-term care outcomes, and safety constraints.

DementiaBank-Emotion: A Multi-Rater Emotion Annotation Corpus for Alzheimer's Disease Speech (Version 1.0)

We present DementiaBank-Emotion, the first multi-rater emotion annotation corpus for Alzheimer's disease (AD) speech. Annotating 1,492 utterances from 108 speakers for Ekman's six basic emotions and neutral, we find that AD patients express significantly more non-neutral emotions (16.9%) than healthy controls (5.7%; p < .001). Exploratory acoustic analysis suggests a possible dissociation: control speakers showed substantial F0 modulation for sadness (Delta = -3.45 semitones from baseline), whereas AD speakers showed minimal change (Delta = +0.11 semitones; interaction p = .023), though this finding is based on limited samples (sadness: n=5 control, n=15 AD) and requires replication. Within AD speech, loudness differentiates emotion categories, indicating partially preserved emotion-prosody mappings. We release the corpus, annotation guidelines, and calibration workshop materials to support research on emotion recognition in clinical populations.

MedSpeak: A Knowledge Graph-Aided ASR Error Correction Framework for Spoken Medical QA

Spoken question-answering (SQA) systems relying on automatic speech recognition (ASR) often struggle with accurately recognizing medical terminology. To this end, we propose MedSpeak, a novel knowledge graph-aided ASR error correction framework that refines noisy transcripts and improves downstream answer prediction by leveraging both semantic relationships and phonetic information encoded in a medical knowledge graph, together with the reasoning power of LLMs. Comprehensive experimental results on benchmarks demonstrate that MedSpeak significantly improves the accuracy of medical term recognition and overall medical SQA performance, establishing MedSpeak as a state-of-the-art solution for medical SQA. The code is available at https://github.com/RainieLLM/MedSpeak.

Styles + Persona-plug = Customized LLMs

We discover a previously overlooked challenge in personalized text generation: personalization methods are increasingly applied under explicit style instructions, yet their behavior under such constraints remains poorly understood. To balance implicit personalization and explicit style, we formulate personalization as a distributional residual and propose PsPLUG, a lightweight soft-prompt plug-in trained with style-conditioned preference contrasts. Across LaMP benchmark, our framework improves persona alignment, maintains stylistic fidelity, and outperforms retrieval-based and soft-prompt baselines with minimal computation. These results show that residual modeling provides a simple and principled foundation for controllable, style-aware LLM personalization.

CARD: Cluster-level Adaptation with Reward-guided Decoding for Personalized Text Generation

Adapting large language models to individual users remains challenging due to the tension between fine-grained personalization and scalable deployment. We present CARD, a hierarchical framework that achieves effective personalization through progressive refinement. CARD first clusters users according to shared stylistic patterns and learns cluster-specific LoRA adapters, enabling robust generalization and strong low-resource performance. To capture individual differences within each cluster, we propose an implicit preference learning mechanism that contrasts user-authored text with cluster-level generations, allowing the model to infer user-specific style preferences without manual annotation. At inference time, CARD injects personalization exclusively at decoding via lightweight user preference vectors and low-rank logit corrections, while keeping the base model frozen. Experiments on the LaMP and LongLaMP benchmarks show that CARD achieves competitive or superior generation quality compared to state-of-the-art baselines, while significantly improving efficiency and scalability for practical personalized text generation.

ADGSyn: Dual-Stream Learning for Efficient Anticancer Drug Synergy Prediction

Drug combinations play a critical role in cancer therapy by significantly enhancing treatment efficacy and overcoming drug resistance. However, the combinatorial space of possible drug pairs grows exponentially, making experimental screening highly impractical. Therefore, developing efficient computational methods to predict promising drug combinations and guide experimental validation is of paramount importance. In this work, we propose ADGSyn, an innovative method for predicting drug synergy. The key components of our approach include: (1) shared projection matrices combined with attention mechanisms to enable cross-drug feature alignment; (2) automatic mixed precision (AMP)-optimized graph operations that reduce memory consumption by 40\% while accelerating training speed threefold; and (3) residual pathways stabilized by LayerNorm to ensure stable gradient propagation during training. Evaluated on the O'Neil dataset containing 13,243 drug--cell line combinations, ADGSyn demonstrates superior performance over eight baseline methods. Moreover, the framework supports full-batch processing of up to 256 molecular graphs on a single GPU, setting a new standard for efficiency in drug synergy prediction within the field of computational oncology.

DEMENTIA-PLAN: An Agent-Based Framework for Multi-Knowledge Graph Retrieval-Augmented Generation in Dementia Care

Mild-stage dementia patients primarily experience two critical symptoms: severe memory loss and emotional instability. To address these challenges, we propose DEMENTIA-PLAN, an innovative retrieval-augmented generation framework that leverages large language models to enhance conversational support. Our model employs a multiple knowledge graph architecture, integrating various dimensional knowledge representations including daily routine graphs and life memory graphs. Through this multi-graph architecture, DEMENTIA-PLAN comprehensively addresses both immediate care needs and facilitates deeper emotional resonance through personal memories, helping stabilize patient mood while providing reliable memory support. Our notable innovation is the self-reflection planning agent, which systematically coordinates knowledge retrieval and semantic integration across multiple knowledge graphs, while scoring retrieved content from daily routine and life memory graphs to dynamically adjust their retrieval weights for optimized response generation. DEMENTIA-PLAN represents a significant advancement in the clinical application of large language models for dementia care, bridging the gap between AI tools and caregivers interventions.