A Hierarchical Descriptor Framework for On-the-Fly Anatomical Location Matching between Longitudinal Studies

We propose a method to match anatomical locations between pairs of medical images in longitudinal comparisons. The matching is made possible by computing a descriptor of the query point in a source image based on a hierarchical sparse sampling of image intensities that encode the location information. Then, a hierarchical search operation finds the corresponding point with the most similar descriptor in the target image. This simple yet powerful strategy reduces the computational time of mapping points to a millisecond scale on a single CPU. Thus, radiologists can compare similar anatomical locations in near real-time without requiring extra architectural costs for precomputing or storing deformation fields from registrations. Our algorithm does not require prior training, resampling, segmentation, or affine transformation steps. We have tested our algorithm on the recently published Deep Lesion Tracking dataset annotations. We observed more accurate matching compared to Deep Lesion Tracker while being 24 times faster than the most precise algorithm reported therein. We also investigated the matching accuracy on CT and MR modalities and compared the proposed algorithm's accuracy against ground truth consolidated from multiple radiologists.

Dual-Domain Cross-Iteration Squeeze-Excitation Network for Sparse Reconstruction of Brain MRI

Magnetic resonance imaging (MRI) is one of the most commonly applied tests in neurology and neurosurgery. However, the utility of MRI is largely limited by its long acquisition time, which might induce many problems including patient discomfort and motion artifacts. Acquiring fewer k-space sampling is a potential solution to reducing the total scanning time. However, it can lead to severe aliasing reconstruction artifacts and thus affect the clinical diagnosis. Nowadays, deep learning has provided new insights into the sparse reconstruction of MRI. In this paper, we present a new approach to this problem that iteratively fuses the information of k-space and MRI images using novel dual Squeeze-Excitation Networks and Cross-Iteration Residual Connections. This study included 720 clinical multi-coil brain MRI cases adopted from the open-source deidentified fastMRI Dataset. 8-folder downsampling rate was applied to generate the sparse k-space. Results showed that the average reconstruction error over 120 testing cases by our proposed method was 2.28%, which outperformed the existing image-domain prediction (6.03%, p<0.001), k-space synthesis (6.12%, p<0.001), and dual-domain feature fusion (4.05%, p<0.001).

Supervised Understanding of Word Embeddings

Pre-trained word embeddings are widely used for transfer learning in natural language processing. The embeddings are continuous and distributed representations of the words that preserve their similarities in compact Euclidean spaces. However, the dimensions of these spaces do not provide any clear interpretation. In this study, we have obtained supervised projections in the form of the linear keyword-level classifiers on word embeddings. We have shown that the method creates interpretable projections of original embedding dimensions. Activations of the trained classifier nodes correspond to a subset of the words in the vocabulary. Thus, they behave similarly to the dictionary features while having the merit of continuous value output. Additionally, such dictionaries can be grown iteratively with multiple rounds by adding expert labels on top-scoring words to an initial collection of the keywords. Also, the same classifiers can be applied to aligned word embeddings in other languages to obtain corresponding dictionaries. In our experiments, we have shown that initializing higher-order networks with these classifier weights gives more accurate models for downstream NLP tasks. We further demonstrate the usefulness of supervised dimensions in revealing the polysemous nature of a keyword of interest by projecting it's embedding using learned classifiers in different sub-spaces.

Hierarchical Latent Word Clustering

This paper presents a new Bayesian non-parametric model by extending the usage of Hierarchical Dirichlet Allocation to extract tree structured word clusters from text data. The inference algorithm of the model collects words in a cluster if they share similar distribution over documents. In our experiments, we observed meaningful hierarchical structures on NIPS corpus and radiology reports collected from public repositories.