Organ-Agents: Virtual Human Physiology Simulator via LLMs

Recent advances in large language models (LLMs) have enabled new possibilities in simulating complex physiological systems. We introduce Organ-Agents, a multi-agent framework that simulates human physiology via LLM-driven agents. Each Simulator models a specific system (e.g., cardiovascular, renal, immune). Training consists of supervised fine-tuning on system-specific time-series data, followed by reinforcement-guided coordination using dynamic reference selection and error correction. We curated data from 7,134 sepsis patients and 7,895 controls, generating high-resolution trajectories across 9 systems and 125 variables. Organ-Agents achieved high simulation accuracy on 4,509 held-out patients, with per-system MSEs <0.16 and robustness across SOFA-based severity strata. External validation on 22,689 ICU patients from two hospitals showed moderate degradation under distribution shifts with stable simulation. Organ-Agents faithfully reproduces critical multi-system events (e.g., hypotension, hyperlactatemia, hypoxemia) with coherent timing and phase progression. Evaluation by 15 critical care physicians confirmed realism and physiological plausibility (mean Likert ratings 3.9 and 3.7). Organ-Agents also enables counterfactual simulations under alternative sepsis treatment strategies, generating trajectories and APACHE II scores aligned with matched real-world patients. In downstream early warning tasks, classifiers trained on synthetic data showed minimal AUROC drops (<0.04), indicating preserved decision-relevant patterns. These results position Organ-Agents as a credible, interpretable, and generalizable digital twin for precision diagnosis, treatment simulation, and hypothesis testing in critical care.

Causal Disentanglement Hidden Markov Model for Fault Diagnosis

In modern industries, fault diagnosis has been widely applied with the goal of realizing predictive maintenance. The key issue for the fault diagnosis system is to extract representative characteristics of the fault signal and then accurately predict the fault type. In this paper, we propose a Causal Disentanglement Hidden Markov model (CDHM) to learn the causality in the bearing fault mechanism and thus, capture their characteristics to achieve a more robust representation. Specifically, we make full use of the time-series data and progressively disentangle the vibration signal into fault-relevant and fault-irrelevant factors. The ELBO is reformulated to optimize the learning of the causal disentanglement Markov model. Moreover, to expand the scope of the application, we adopt unsupervised domain adaptation to transfer the learned disentangled representations to other working environments. Experiments were conducted on the CWRU dataset and IMS dataset. Relevant results validate the superiority of the proposed method.