Stroke Lesions as a Rosetta Stone for Language Model Interpretability

Large language models (LLMs) have achieved remarkable capabilities, yet methods to verify which model components are truly necessary for language function remain limited. Current interpretability approaches rely on internal metrics and lack external validation. Here we present the Brain-LLM Unified Model (BLUM), a framework that leverages lesion-symptom mapping, the gold standard for establishing causal brain-behavior relationships for over a century, as an external reference structure for evaluating LLM perturbation effects. Using data from individuals with chronic post-stroke aphasia (N = 410), we trained symptom-to-lesion models that predict brain damage location from behavioral error profiles, applied systematic perturbations to transformer layers, administered identical clinical assessments to perturbed LLMs and human patients, and projected LLM error profiles into human lesion space. LLM error profiles were sufficiently similar to human error profiles that predicted lesions corresponded to actual lesions in error-matched humans above chance in 67% of picture naming conditions (p < 10^{-23}) and 68.3% of sentence completion conditions (p < 10^{-61}), with semantic-dominant errors mapping onto ventral-stream lesion patterns and phonemic-dominant errors onto dorsal-stream patterns. These findings open a new methodological avenue for LLM interpretability in which clinical neuroscience provides external validation, establishing human lesion-symptom mapping as a reference framework for evaluating artificial language systems and motivating direct investigation of whether behavioral alignment reflects shared computational principles.

Thick-Net: Parallel Network Structure for Sequential Modeling

Recurrent neural networks have been widely used in sequence learning tasks. In previous studies, the performance of the model has always been improved by either wider or deeper structures. However, the former becomes more prone to overfitting, while the latter is difficult to optimize. In this paper, we propose a simple new model named Thick-Net, by expanding the network from another dimension: thickness. Multiple parallel values are obtained via more sets of parameters in each hidden state, and the maximum value is selected as the final output among parallel intermediate outputs. Notably, Thick-Net can efficiently avoid overfitting, and is easier to optimize than the vanilla structures due to the large dropout affiliated with it. Our model is evaluated on four sequential tasks including adding problem, permuted sequential MNIST, text classification and language modeling. The results of these tasks demonstrate that our model can not only improve accuracy with faster convergence but also facilitate a better generalization ability.