Diffusion-based Aesthetic QR Code Generation via Scanning-Robust Perceptual Guidance

QR codes, prevalent in daily applications, lack visual appeal due to their conventional black-and-white design. Integrating aesthetics while maintaining scannability poses a challenge. In this paper, we introduce a novel diffusion-model-based aesthetic QR code generation pipeline, utilizing pre-trained ControlNet and guided iterative refinement via a novel classifier guidance (SRG) based on the proposed Scanning-Robust Loss (SRL) tailored with QR code mechanisms, which ensures both aesthetics and scannability. To further improve the scannability while preserving aesthetics, we propose a two-stage pipeline with Scanning-Robust Perceptual Guidance (SRPG). Moreover, we can further enhance the scannability of the generated QR code by post-processing it through the proposed Scanning-Robust Projected Gradient Descent (SRPGD) post-processing technique based on SRL with proven convergence. With extensive quantitative, qualitative, and subjective experiments, the results demonstrate that the proposed approach can generate diverse aesthetic QR codes with flexibility in detail. In addition, our pipelines outperforming existing models in terms of Scanning Success Rate (SSR) 86.67% (+40%) with comparable aesthetic scores. The pipeline combined with SRPGD further achieves 96.67% (+50%). Our code will be available https://github.com/jwliao1209/DiffQRCode.

Prediction of Small Molecule Kinase Inhibitors for Chemotherapy Using Deep Learning

The current state of cancer therapeutics has been moving away from one-size-fits-all cytotoxic chemotherapy, and towards a more individualized and specific approach involving the targeting of each tumor's genetic vulnerabilities. Different tumors, even of the same type, may be more reliant on certain cellular pathways more than others. With modern advancements in our understanding of cancer genome sequencing, these pathways can be discovered. Investigating each of the millions of possible small molecule inhibitors for each kinase in vitro, however, would be extremely expensive and time consuming. This project focuses on predicting the inhibition activity of small molecules targeting 8 different kinases using multiple deep learning models. We trained fingerprint-based MLPs and simplified molecular-input line-entry specification (SMILES)-based recurrent neural networks (RNNs) and molecular graph convolutional networks (GCNs) to accurately predict inhibitory activity targeting these 8 kinases.