Plane Wave Elastography: A Frequency-Domain Ultrasound Shear Wave Elastography Approach

In this paper, we propose Plane Wave Elastography (PWE), a novel ultrasound shear wave elastography (SWE) approach. Currently, commercial methods for SWE rely on directional filtering based on the prior knowledge of the wave propagation direction, to remove complicated wave patterns formed due to reflection and refraction. The result is a set of decomposed directional waves that are separately analyzed to construct shear modulus fields that are then combined through compounding. Instead, PWE relies on a rigorous representation of the wave propagation using the frequency-domain scalar wave equation to automatically select appropriate propagation directions and simultaneously reconstruct shear modulus fields. Specifically, assuming a homogeneous, isotropic, incompressible, linear-elastic medium, we represent the solution of the wave equation using a linear combination of plane waves propagating in arbitrary directions. Given this closed-form solution, we formulate the SWE problem as a nonlinear least-squares optimization problem which can be solved very efficiently. Through numerous phantom studies, we show that PWE can handle complicated waveforms without prior filtering and is competitive with state-of-the-art that requires prior filtering based on the knowledge of propagation directions.

Adaptive particle-based approximations of the Gibbs posterior for inverse problems

In this work, we adopt a general framework based on the Gibbs posterior to update belief distributions for inverse problems governed by partial differential equations (PDEs). The Gibbs posterior formulation is a generalization of standard Bayesian inference that only relies on a loss function connecting the unknown parameters to the data. It is particularly useful when the true data generating mechanism (or noise distribution) is unknown or difficult to specify. The Gibbs posterior coincides with Bayesian updating when a true likelihood function is known and the loss function corresponds to the negative log-likelihood, yet provides subjective inference in more general settings. We employ a sequential Monte Carlo (SMC) approach to approximate the Gibbs posterior using particles. To manage the computational cost of propagating increasing numbers of particles through the loss function, we employ a recently developed local reduced basis method to build an efficient surrogate loss function that is used in the Gibbs update formula in place of the true loss. We derive error bounds for our approximation and propose an adaptive approach to construct the surrogate model in an efficient manner. We demonstrate the efficiency of our approach through several numerical examples.

Model-Based Active Source Identification in Complex Environments

We consider the problem of Active Source Identification (ASI) in steady-state Advection-Diffusion (AD) transport systems. Unlike existing bio-inspired heuristic methods, we propose a model-based method that employs the AD-PDE to capture the transport phenomenon. Specifically, we formulate the Source Identification (SI) problem as a PDE-constrained optimization problem in function spaces. To obtain a tractable solution, we reduce the dimension of the concentration field using Proper Orthogonal Decomposition and approximate the unknown source field using nonlinear basis functions, drastically decreasing the number of unknowns. Moreover, to collect the concentration measurements, we control a robot sensor through a sequence of waypoints that maximize the smallest eigenvalue of the Fisher Information matrix of the unknown source parameters. Specifically, after every new measurement, a SI problem is solved to obtain a source estimate that is used to determine the next waypoint. We show that our algorithm can efficiently identify sources in complex AD systems and non-convex domains, in simulation and experimentally. This is the first time that PDEs are used for robotic SI in practice.