Super-Resolution Optical Coherence Tomography Using Diffusion Model-Based Plug-and-Play Priors

We propose an OCT super-resolution framework based on a plug-and-play diffusion model (PnP-DM) to reconstruct high-quality images from sparse measurements (OCT B-mode corneal images). Our method formulates reconstruction as an inverse problem, combining a diffusion prior with Markov chain Monte Carlo sampling for efficient posterior inference. We collect high-speed under-sampled B-mode corneal images and apply a deep learning-based up-sampling pipeline to build realistic training pairs. Evaluations on in vivo and ex vivo fish-eye corneal models show that PnP-DM outperforms conventional 2D-UNet baselines, producing sharper structures and better noise suppression. This approach advances high-fidelity OCT imaging in high-speed acquisition for clinical applications.

Neural Inverse Scattering with Score-based Regularization

Inverse scattering is a fundamental challenge in many imaging applications, ranging from microscopy to remote sensing. Solving this problem often requires jointly estimating two unknowns -- the image and the scattering field inside the object -- necessitating effective image prior to regularize the inference. In this paper, we propose a regularized neural field (NF) approach which integrates the denoising score function used in score-based generative models. The neural field formulation offers convenient flexibility to performing joint estimation, while the denoising score function imposes the rich structural prior of images. Our results on three high-contrast simulated objects show that the proposed approach yields a better imaging quality compared to the state-of-the-art NF approach, where regularization is based on total variation.