DeCo-MIL: Debiased Counterfactual Reasoning for Long-Tailed Whole Slide Image Analysis

Multiple instance learning (MIL) is widely used for weakly supervised whole slide image (WSI) analysis. However, under long-tailed distributions, MIL-based WSI analysis faces a nested dual long-tail: an inter-slide class long tail and an intra-slide long tail of instance-level discriminative evidence. The two long tails are coupled: tail classes have few training slides, while their limited diagnostic evidence is concentrated in a few patches and obscured by abundant within-bag redundancy. This coupling biases models toward head classes and degrades rare-class recognition. To address this, we propose DeCo-MIL for long-tailed WSI analysis, which jointly alleviates the nested dual long-tail through frequency-debiased counterfactual reasoning. For the inner long tail, DeCo-MIL clusters patches into tissue-morphology anchors, replaces each anchor with its matched normal prototype to perform a counterfactual intervention, and estimates its counterfactual contribution to the ground-truth class using class-frequency-corrected predictions. These contributions guide redundancy masking to preserve scarce discriminative instances. For the outer long tail, DeCo-MIL constructs anchor-stratified pseudo-bags from redundancy-reduced bags and combines tail-aware oversampling with consistency regularization, increasing effective supervision for tail classes while preserving tissue-morphology composition. Extensive experiments on three long-tailed WSI benchmarks demonstrate that DeCo-MIL achieves state-of-the-art performance in both tail-class recognition and overall classification.

In-Loop Model Adaptation with Coupled Latent-Noise Guidance for High-Fidelity Subject-Driven Text-to-Image Generation

Text-to-image diffusion models have achieved remarkable success in generating high-quality images from a given text prompt. Subject-driven generation aims to synthesize customized images to mimic the appearance of subjects in given reference images within different visual contexts specified by the text prompts. The central challenge here is that, when the reference image changes, the diffusion model cannot efficiently adapt to different visual contexts while consistently maintaining the subject identity. Existing methods either train the model with a large domain-specific dataset or fine-tune the model using the reference image for hundreds of iterations before actual image generation. In this work, we explore a new approach, called \textit{In-Loop Model Adaptation} (IMA), which adapts the core diffusion model at each generation step during the actual process of image generation, without being trained on the reference image before the generation process. To this end, we establish a DDIM inversion chain that maps the reference image to a sequence of latent, as well as a text-to-image generation chain which generates the image from the text prompt only. We then introduce a masked latent consistency loss and a noise regularization loss to characterize the latent-noise difference between the diffusion model and these two chains at each generation step. This coupled latent-noise loss is used to guide the in-loop model adaptation to preserve the subject identity specified by the reference image while maintaining accurate alignment with the text prompt, resulting in high-fidelity text-to-image generation. Our extensive experiments demonstrate that our proposed IMA method significantly improves the performance of subject-driven text-to-image generation.

Latent Bias Alignment for High-Fidelity Diffusion Inversion in Real-World Image Reconstruction and Manipulation

Recent research has shown that text-to-image diffusion models are capable of generating high-quality images guided by text prompts. But can they be used to generate or approximate real-world images from the seed noise? This is known as the diffusion inversion problem, which serves as a fundamental building block for bridging diffusion models and real-world scenarios. However, existing diffusion inversion methods often suffer from low reconstruction quality or weak robustness. Two major challenges need to be carefully addressed: (1) the misalignment between the inversion and generation trajectories during the diffusion process, and (2) the mismatch between the diffusion inversion process and the VQ autoencoder (VQAE) reconstruction. To address these challenges, we introduce a latent bias vector at each inversion step, which is learned to reduce the misalignment between inversion and generation trajectories. We refer to this strategy as Latent Bias Optimization (LBO). Furthermore, we perform an approximate joint optimization of the diffusion inversion and VQAE reconstruction processes by learning to adjust the image latent representation, which serves as the connecting interface between them. We refer to this technique as Image Latent Boosting (ILB). Extensive experimental results demonstrate that the proposed method significantly improves the image reconstruction quality of the diffusion model, as well as the performance of downstream tasks, including image editing and rare concept generation.

To What Extent Do Token-Level Representations from Pathology Foundation Models Improve Dense Prediction?

Pathology foundation models (PFMs) have rapidly advanced and are becoming a common backbone for downstream clinical tasks, offering strong transferability across tissues and institutions. However, for dense prediction (e.g., segmentation), practical deployment still lacks a clear, reproducible understanding of how different PFMs behave across datasets and how adaptation choices affect performance and stability. We present PFM-DenseBench, a large-scale benchmark for dense pathology prediction, evaluating 17 PFMs across 18 public segmentation datasets. Under a unified protocol, we systematically assess PFMs with multiple adaptation and fine-tuning strategies, and derive insightful, practice-oriented findings on when and why different PFMs and tuning choices succeed or fail across heterogeneous datasets. We release containers, configs, and dataset cards to enable reproducible evaluation and informed PFM selection for real-world dense pathology tasks. Project Website: https://m4a1tastegood.github.io/PFM-DenseBench

Understanding the Implicit User Intention via Reasoning with Large Language Model for Image Editing

Existing image editing methods can handle simple editing instructions very well. To deal with complex editing instructions, they often need to jointly fine-tune the large language models (LLMs) and diffusion models (DMs), which involves very high computational complexity and training cost. To address this issue, we propose a new method, called \textbf{C}omplex \textbf{I}mage \textbf{E}diting via \textbf{L}LM \textbf{R}easoning (CIELR), which converts a complex user instruction into a set of simple and explicit editing actions, eliminating the need for jointly fine-tuning the large language models and diffusion models. Specifically, we first construct a structured semantic representation of the input image using foundation models. Then, we introduce an iterative update mechanism that can progressively refine this representation, obtaining a fine-grained visual representation of the image scene. This allows us to perform complex and flexible image editing tasks. Extensive experiments on the SmartEdit Reasoning Scenario Set show that our method surpasses the previous state-of-the-art by 9.955 dB in PSNR, indicating its superior preservation of regions that should remain consistent. Due to the limited number of samples of public datasets of complex image editing with reasoning, we construct a benchmark named CIEBench, containing 86 image samples, together with a metric specifically for reasoning-based image editing. CIELR also outperforms previous methods on this benchmark. The code and dataset are available at \href{https://github.com/Jia-shao/Reasoning-Editing}{https://github.com/Jia-shao/Reasoning-Editing}.

Generative Semantic Coding for Ultra-Low Bitrate Visual Communication and Analysis

We consider the problem of ultra-low bit rate visual communication for remote vision analysis, human interactions and control in challenging scenarios with very low communication bandwidth, such as deep space exploration, battlefield intelligence, and robot navigation in complex environments. In this paper, we ask the following important question: can we accurately reconstruct the visual scene using only a very small portion of the bit rate in existing coding methods while not sacrificing the accuracy of vision analysis and performance of human interactions? Existing text-to-image generation models offer a new approach for ultra-low bitrate image description. However, they can only achieve a semantic-level approximation of the visual scene, which is far insufficient for the purpose of visual communication and remote vision analysis and human interactions. To address this important issue, we propose to seamlessly integrate image generation with deep image compression, using joint text and coding latent to guide the rectified flow models for precise generation of the visual scene. The semantic text description and coding latent are both encoded and transmitted to the decoder at a very small bit rate. Experimental results demonstrate that our method can achieve the same image reconstruction quality and vision analysis accuracy as existing methods while using much less bandwidth. The code will be released upon paper acceptance.

Runge-Kutta Approximation and Decoupled Attention for Rectified Flow Inversion and Semantic Editing

Rectified flow (RF) models have recently demonstrated superior generative performance compared to DDIM-based diffusion models. However, in real-world applications, they suffer from two major challenges: (1) low inversion accuracy that hinders the consistency with the source image, and (2) entangled multimodal attention in diffusion transformers, which hinders precise attention control. To address the first challenge, we propose an efficient high-order inversion method for rectified flow models based on the Runge-Kutta solver of differential equations. To tackle the second challenge, we introduce Decoupled Diffusion Transformer Attention (DDTA), a novel mechanism that disentangles text and image attention inside the multimodal diffusion transformers, enabling more precise semantic control. Extensive experiments on image reconstruction and text-guided editing tasks demonstrate that our method achieves state-of-the-art performance in terms of fidelity and editability. Code is available at https://github.com/wmchen/RKSovler_DDTA.