A Framework for Cross-Domain Generalization in Coronary Artery Calcium Scoring Across Gated and Non-Gated Computed Tomography

Coronary artery calcium (CAC) scoring is a key predictor of cardiovascular risk, but it relies on ECG-gated CT scans, restricting its use to specialized cardiac imaging settings. We introduce an automated framework for CAC detection and lesion-specific Agatston scoring that operates across both gated and non-gated CT scans. At its core is CARD-ViT, a self-supervised Vision Transformer trained exclusively on gated CT data using DINO. Without any non-gated training data, our framework achieves 0.707 accuracy and a Cohen's kappa of 0.528 on the Stanford non-gated dataset, matching models trained directly on non-gated scans. On gated test sets, the framework achieves 0.910 accuracy with Cohen's kappa scores of 0.871 and 0.874 across independent datasets, demonstrating robust risk stratification. These results demonstrate the feasibility of cross-domain CAC scoring from gated to non-gated domains, supporting scalable cardiovascular screening in routine chest imaging without additional scans or annotations.

EduceLab-Scrolls: Verifiable Recovery of Text from Herculaneum Papyri using X-ray CT

We present a complete software pipeline for revealing the hidden texts of the Herculaneum papyri using X-ray CT images. This enhanced virtual unwrapping pipeline combines machine learning with a novel geometric framework linking 3D and 2D images. We also present EduceLab-Scrolls, a comprehensive open dataset representing two decades of research effort on this problem. EduceLab-Scrolls contains a set of volumetric X-ray CT images of both small fragments and intact, rolled scrolls. The dataset also contains 2D image labels that are used in the supervised training of an ink detection model. Labeling is enabled by aligning spectral photography of scroll fragments with X-ray CT images of the same fragments, thus creating a machine-learnable mapping between image spaces and modalities. This alignment permits supervised learning for the detection of "invisible" carbon ink in X-ray CT, a task that is "impossible" even for human expert labelers. To our knowledge, this is the first aligned dataset of its kind and is the largest dataset ever released in the heritage domain. Our method is capable of revealing accurate lines of text on scroll fragments with known ground truth. Revealed text is verified using visual confirmation, quantitative image metrics, and scholarly review. EduceLab-Scrolls has also enabled the discovery, for the first time, of hidden texts from the Herculaneum papyri, which we present here. We anticipate that the EduceLab-Scrolls dataset will generate more textual discovery as research continues.