Voice Pathology Detection Using Phonation

Voice disorders significantly affect communication and quality of life, requiring an early and accurate diagnosis. Traditional methods like laryngoscopy are invasive, subjective, and often inaccessible. This research proposes a noninvasive, machine learning-based framework for detecting voice pathologies using phonation data. Phonation data from the Saarbr\"ucken Voice Database are analyzed using acoustic features such as Mel Frequency Cepstral Coefficients (MFCCs), chroma features, and Mel spectrograms. Recurrent Neural Networks (RNNs), including LSTM and attention mechanisms, classify samples into normal and pathological categories. Data augmentation techniques, including pitch shifting and Gaussian noise addition, enhance model generalizability, while preprocessing ensures signal quality. Scale-based features, such as H\"older and Hurst exponents, further capture signal irregularities and long-term dependencies. The proposed framework offers a noninvasive, automated diagnostic tool for early detection of voice pathologies, supporting AI-driven healthcare, and improving patient outcomes.

Identification of Patterns of Cognitive Impairment for Early Detection of Dementia

Early detection of dementia is crucial to devise effective interventions. Comprehensive cognitive tests, while being the most accurate means of diagnosis, are long and tedious, thus limiting their applicability to a large population, especially when periodic assessments are needed. The problem is compounded by the fact that people have differing patterns of cognitive impairment as they progress to different forms of dementia. This paper presents a novel scheme by which individual-specific patterns of impairment can be identified and used to devise personalized tests for periodic follow-up. Patterns of cognitive impairment are initially learned from a population cluster of combined normals and MCIs, using a set of standardized cognitive tests. Impairment patterns in the population are identified using a 2-step procedure involving an ensemble wrapper feature selection followed by cluster identification and analysis. These patterns have been shown to correspond to clinically accepted variants of MCI, a prodrome of dementia. The learned clusters of patterns can subsequently be used to identify the most likely route of cognitive impairment, even for pre-symptomatic and apparently normal people. Baseline data of 24,000 subjects from the NACC database was used for the study.