Identification of Patterns of Cognitive Impairment for Early Detection of Dementia

Early detection of dementia is crucial to devise effective interventions. Comprehensive cognitive tests, while being the most accurate means of diagnosis, are long and tedious, thus limiting their applicability to a large population, especially when periodic assessments are needed. The problem is compounded by the fact that people have differing patterns of cognitive impairment as they progress to different forms of dementia. This paper presents a novel scheme by which individual-specific patterns of impairment can be identified and used to devise personalized tests for periodic follow-up. Patterns of cognitive impairment are initially learned from a population cluster of combined normals and MCIs, using a set of standardized cognitive tests. Impairment patterns in the population are identified using a 2-step procedure involving an ensemble wrapper feature selection followed by cluster identification and analysis. These patterns have been shown to correspond to clinically accepted variants of MCI, a prodrome of dementia. The learned clusters of patterns can subsequently be used to identify the most likely route of cognitive impairment, even for pre-symptomatic and apparently normal people. Baseline data of 24,000 subjects from the NACC database was used for the study.

Brain-scale Theta Band Functional Connectivity As A Signature of Slow Breathing and Breath-hold Phases

The study reported herein attempts to understand the neural mechanisms engaged in the conscious control of breathing and breath-hold. The variations in the electroencephalogram (EEG) based functional connectivity (FC) of the human brain during consciously controlled breathing at 2 cycles per minute (cpm), and breath-hold have been investigated and reported here. An experimental protocol involving controlled breathing and breath-hold sessions, synchronized to a visual metronome, was designed and administered to 20 healthy subjects (9 females and 11 males). EEG data were collected during these sessions using the 61-channel eego mylab system from ANT Neuro. Further, FC was estimated for all possible pairs of EEG time series data, for 7 EEG bands. Feature selection using a genetic algorithm (GA) was performed to identify a subset of functional connections that would best distinguish the inhale, exhale, inhale-hold, and exhale-hold phases using a random committee classifier. The best accuracy of 93.36 % was obtained when 1161 theta-band functional connections were fed as input to the classifier, highlighting the efficacy of the theta-band functional connectome in distinguishing these phases of the respiratory cycle. This functional network was further characterized using graph measures, and observations illustrated a statistically significant difference in the efficiency of information exchange through the network during different respiratory phases.