Generative Modeling of Neurodegenerative Brain Anatomy with 4D Longitudinal Diffusion Model

Understanding and predicting the progression of neurodegenerative diseases remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning. However, most available longitudinal neuroimaging datasets are temporally sparse with a few follow-up scans per subject. This scarcity of temporal data limits our ability to model and accurately capture the continuous anatomical changes related to disease progression in individual subjects. To address this problem, we propose a novel 4D (3DxT) diffusion-based generative framework that effectively models and synthesizes longitudinal brain anatomy over time, conditioned on available clinical variables such as health status, age, sex, and other relevant factors. Moreover, while most current approaches focus on manipulating image intensity or texture, our method explicitly learns the data distribution of topology-preserving spatiotemporal deformations to effectively capture the geometric changes of brain structures over time. This design enables the realistic generation of future anatomical states and the reconstruction of anatomically consistent disease trajectories, providing a more faithful representation of longitudinal brain changes. We validate our model through both synthetic sequence generation and downstream longitudinal disease classification, as well as brain segmentation. Experiments on two large-scale longitudinal neuroimage datasets demonstrate that our method outperforms state-of-the-art baselines in generating anatomically accurate, temporally consistent, and clinically meaningful brain trajectories. Our code is available on Github.

MF-GCN: A Multi-Frequency Graph Convolutional Network for Tri-Modal Depression Detection Using Eye-Tracking, Facial, and Acoustic Features

Eye tracking data quantifies the attentional bias towards negative stimuli that is frequently observed in depressed groups. Audio and video data capture the affective flattening and psychomotor retardation characteristic of depression. Statistical validation confirmed their significant discriminative power in distinguishing depressed from non depressed groups. We address a critical limitation of existing graph-based models that focus on low-frequency information and propose a Multi-Frequency Graph Convolutional Network (MF-GCN). This framework consists of a novel Multi-Frequency Filter Bank Module (MFFBM), which can leverage both low and high frequency signals. Extensive evaluation against traditional machine learning algorithms and deep learning frameworks demonstrates that MF-GCN consistently outperforms baselines. In binary (depressed and non depressed) classification, the model achieved a sensitivity of 0.96 and F2 score of 0.94. For the 3 class (no depression, mild to moderate depression and severe depression) classification task, the proposed method achieved a sensitivity of 0.79 and specificity of 0.87 and siginificantly suprassed other models. To validate generalizability, the model was also evaluated on the Chinese Multimodal Depression Corpus (CMDC) dataset and achieved a sensitivity of 0.95 and F2 score of 0.96. These results confirm that our trimodal, multi frequency framework effectively captures cross modal interaction for accurate depression detection.