ZC-Swish: Stabilizing Deep BN-Free Networks for Edge and Micro-Batch Applications

Batch Normalization (BN) is a cornerstone of deep learning, yet it fundamentally breaks down in micro-batch regimes (e.g., 3D medical imaging) and non-IID Federated Learning. Removing BN from deep architectures, however, often leads to catastrophic training failures such as vanishing gradients and dying channels. We identify that standard activation functions, like Swish and ReLU, exacerbate this instability in BN-free networks due to their non-zero-centered nature, which causes compounding activation mean-shifts as network depth increases. In this technical communication, we propose Zero-Centered Swish (ZC-Swish), a drop-in activation function parameterized to dynamically anchor activation means near zero. Through targeted stress-testing on BN-free convolutional networks at depths 8, 16, and 32, we demonstrate that while standard Swish collapses to near-random performance at depth 16 and beyond, ZC-Swish maintains stable layer-wise activation dynamics and achieves the highest test accuracy at depth 16 (51.5%) with seed 42. ZC-Swish thus provides a robust, parameter-efficient solution for stabilizing deep networks in memory-constrained and privacy-preserving applications where traditional normalization is unviable.

From Literature to Hypotheses: An AI Co-Scientist System for Biomarker-Guided Drug Combination Hypothesis Generation

The rapid growth of biomedical literature and curated databases has made it increasingly difficult for researchers to systematically connect biomarker mechanisms to actionable drug combination hypotheses. We present AI Co-Scientist (CoDHy), an interactive, human-in-the-loop system for biomarker-guided drug combination hypothesis generation in cancer research. CoDHy integrates structured biomedical databases and unstructured literature evidence into a task-specific knowledge graph, which serves as the basis for graph-based reasoning and hypothesis construction. The system combines knowledge graph embeddings with agent-based reasoning to generate, validate, and rank candidate drug combinations, while explicitly grounding each hypothesis in retrievable evidence. Through a web-based interface, users can configure the scientific context, inspect intermediate results, and iteratively refine hypotheses, enabling transparent and researcher-steerable exploration rather than automated decision-making. We demonstrate CoDHy as a system for exploratory hypothesis generation and decision support in translational oncology, highlighting its design, interaction workflow, and practical use cases.