Neural Responses to Affective Sentences Reveal Signatures of Depression

Major Depressive Disorder (MDD) is a highly prevalent mental health condition, and a deeper understanding of its neurocognitive foundations is essential for identifying how core functions such as emotional and self-referential processing are affected. We investigate how depression alters the temporal dynamics of emotional processing by measuring neural responses to self-referential affective sentences using surface electroencephalography (EEG) in healthy and depressed individuals. Our results reveal significant group-level differences in neural activity during sentence viewing, suggesting disrupted integration of emotional and self-referential information in depression. Deep learning model trained on these responses achieves an area under the receiver operating curve (AUC) of 0.707 in distinguishing healthy from depressed participants, and 0.624 in differentiating depressed subgroups with and without suicidal ideation. Spatial ablations highlight anterior electrodes associated with semantic and affective processing as key contributors. These findings suggest stable, stimulus-driven neural signatures of depression that may inform future diagnostic tools.

Toward Fully-End-to-End Listened Speech Decoding from EEG Signals

Speech decoding from EEG signals is a challenging task, where brain activity is modeled to estimate salient characteristics of acoustic stimuli. We propose FESDE, a novel framework for Fully-End-to-end Speech Decoding from EEG signals. Our approach aims to directly reconstruct listened speech waveforms given EEG signals, where no intermediate acoustic feature processing step is required. The proposed method consists of an EEG module and a speech module along with a connector. The EEG module learns to better represent EEG signals, while the speech module generates speech waveforms from model representations. The connector learns to bridge the distributions of the latent spaces of EEG and speech. The proposed framework is both simple and efficient, by allowing single-step inference, and outperforms prior works on objective metrics. A fine-grained phoneme analysis is conducted to unveil model characteristics of speech decoding. The source code is available here: github.com/lee-jhwn/fesde.