Multimodal Ordinal Modeling of Alzheimer's Disease Severity Using Structural MRI and Clinical Data

Neurodegenerative diseases such as Alzheimer's disease (AD) require accurate and scalable tools for assessing disease severity, yet current clinical staging remains time-intensive and prone to variability. We propose an attention-enhanced multimodal machine learning framework with ordinal regression for automated and interpretable AD severity staging. The framework integrates T1-weighted MRI with demographic and genetic variables and compares unimodal and multimodal architectures using ordinal and non-ordinal prediction heads. Models were trained and validated using cohort-stratified splits derived from the ADNI, AIBL, and NIFD datasets. A strictly held-out test set was constructed using subjects excluded from all training, validation, preprocessing, and hyperparameter tuning procedures, with subject-level splitting employed throughout to prevent data leakage. Among unimodal approaches, the T1-weighted MRI model achieved slightly higher adjacent-stage accuracy (0.963) and agreement with clinical staging (QWK 0.444) than the tabular model (QWK 0.433). Integrating imaging, demographic, and genetic information improved overall performance. The multimodal non-ordinal baseline achieved the lowest prediction error (MAE 0.340), whereas the ordinal multimodal model achieved the highest adjacent-stage accuracy (0.970) and strongest agreement with clinical staging (QWK 0.549). These findings indicate that ordinal formulations better capture the ordered structure of the CDR scale and yield predictions more consistent with clinical staging. Explainability analyses using Grad CAM++ and SHAP demonstrated anatomically and clinically plausible model behavior, supporting transparent decision-making. Overall, attention-based multimodal learning with ordinal regression represents a robust, interpretable, and scalable approach for automated AD severity staging and AI-assisted clinical decision support.

Generative AI: The power of the new education

The effective integration of generative artificial intelligence in education is a fundamental aspect to prepare future generations. This study proposes an accelerated learning methodology in artificial intelligence, focused on its generative capacity, as a way to achieve this goal. It recognizes the challenge of getting teachers to engage with new technologies and adapt their methods in all subjects, not just those related to AI. This methodology not only promotes interest in science, technology, engineering and mathematics, but also facilitates student understanding of the ethical uses and risks associated with AI. Students' perceptions of generative AI are examined, addressing their emotions towards its evolution, evaluation of its ethical implications, and everyday use of AI tools. In addition, AI applications commonly used by students and their integration into other disciplines are investigated. The study aims to provide educators with a deeper understanding of students' perceptions of AI and its relevance in society and in their future career paths.

AutoQML: Automatic Generation and Training of Robust Quantum-Inspired Classifiers by Using Genetic Algorithms on Grayscale Images

We propose a new hybrid system for automatically generating and training quantum-inspired classifiers on grayscale images by using multiobjective genetic algorithms. We define a dynamic fitness function to obtain the smallest possible circuit and highest accuracy on unseen data, ensuring that the proposed technique is generalizable and robust. We minimize the complexity of the generated circuits in terms of the number of entanglement gates by penalizing their appearance. We reduce the size of the images with two dimensionality reduction approaches: principal component analysis (PCA), which is encoded in the individual for optimization purpose, and a small convolutional autoencoder (CAE). These two methods are compared with one another and with a classical nonlinear approach to understand their behaviors and to ensure that the classification ability is due to the quantum circuit and not the preprocessing technique used for dimensionality reduction.

Automatic design of quantum feature maps

We propose a new technique for the automatic generation of optimal ad-hoc ans\"atze for classification by using quantum support vector machine (QSVM). This efficient method is based on NSGA-II multiobjective genetic algorithms which allow both maximize the accuracy and minimize the ansatz size. It is demonstrated the validity of the technique by a practical example with a non-linear dataset, interpreting the resulting circuit and its outputs. We also show other application fields of the technique that reinforce the validity of the method, and a comparison with classical classifiers in order to understand the advantages of using quantum machine learning.