Early detection of hip periprosthetic joint infections through CNN on Computed Tomography images

Early detection of an infection prior to prosthesis removal (e.g., hips, knees or other areas) would provide significant benefits to patients. Currently, the detection task is carried out only retrospectively with a limited number of methods relying on biometric or other medical data. The automatic detection of a periprosthetic joint infection from tomography imaging is a task never addressed before. This study introduces a novel method for early detection of the hip prosthesis infections analyzing Computed Tomography images. The proposed solution is based on a novel ResNeSt Convolutional Neural Network architecture trained on samples from more than 100 patients. The solution showed exceptional performance in detecting infections with an experimental high level of accuracy and F-score.

An Explainable AI System for Automated COVID-19 Assessment and Lesion Categorization from CT-scans

COVID-19 infection caused by SARS-CoV-2 pathogen is a catastrophic pandemic outbreak all over the world with exponential increasing of confirmed cases and, unfortunately, deaths. In this work we propose an AI-powered pipeline, based on the deep-learning paradigm, for automated COVID-19 detection and lesion categorization from CT scans. We first propose a new segmentation module aimed at identifying automatically lung parenchyma and lobes. Next, we combined such segmentation network with classification networks for COVID-19 identification and lesion categorization. We compare the obtained classification results with those obtained by three expert radiologists on a dataset consisting of 162 CT scans. Results showed a sensitivity of 90\% and a specificity of 93.5% for COVID-19 detection, outperforming those yielded by the expert radiologists, and an average lesion categorization accuracy of over 84%. Results also show that a significant role is played by prior lung and lobe segmentation that allowed us to enhance performance by over 20 percent points. The interpretation of the trained AI models, moreover, reveals that the most significant areas for supporting the decision on COVID-19 identification are consistent with the lesions clinically associated to the virus, i.e., crazy paving, consolidation and ground glass. This means that the artificial models are able to discriminate a positive patient from a negative one (both controls and patients with interstitial pneumonia tested negative to COVID) by evaluating the presence of those lesions into CT scans. Finally, the AI models are integrated into a user-friendly GUI to support AI explainability for radiologists, which is publicly available at http://perceivelab.com/covid-ai.