RenderMatte: Exact-Alpha Rendering and Group-Relative Alignment for Image Matting

Image matting is an essential enabling technology for modern visual content production, where foreground extraction determines the realism and editability of downstream creation workflows. However, precise alpha estimation in open-world scenes remains challenging because real foregrounds exhibit highly diverse appearances and opacity patterns. This makes existing methods struggle with semantic ambiguity and fine-grained opacity variation, especially in sparse boundary regions that are fragile and difficult to supervise. To address this gap, we present RenderMatte, a trimap-guided matting framework that adapts FLUX.1 Kontext through full-parameter fine-tuning, leveraging image editing priors for structure-preserving alpha prediction. During supervised adaptation, an alpha-edge objective preserves the latent flow-matching signal while strengthening pixel-space boundary supervision. We further introduce group-relative alpha alignment for post-training. It compares multiple mattes sampled under the same trimap condition using matting-specific rewards for alpha accuracy, boundary fidelity, trimap compliance, and compositional consistency. To overcome the lack of precise edge annotations, we construct the RenderMatte dataset, a large-scale synthetic dataset combining 3D-rendered RGBA foregrounds with diverse multi-source assets. It features exact strand-level alpha annotations and diverse background composites. Experiments show state-of-the-art performance across all benchmarks, demonstrating a scalable path toward high-fidelity matting in open-world scenes.

Phenome-wide causal proteomics enhance systemic lupus erythematosus flare prediction: A study in Asian populations

Objective: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by unpredictable flares. This study aimed to develop a novel proteomics-based risk prediction model specifically for Asian SLE populations to enhance personalized disease management and early intervention. Methods: A longitudinal cohort study was conducted over 48 weeks, including 139 SLE patients monitored every 12 weeks. Patients were classified into flare (n = 53) and non-flare (n = 86) groups. Baseline plasma samples underwent data-independent acquisition (DIA) proteomics analysis, and phenome-wide Mendelian randomization (PheWAS) was performed to evaluate causal relationships between proteins and clinical predictors. Logistic regression (LR) and random forest (RF) models were used to integrate proteomic and clinical data for flare risk prediction. Results: Five proteins (SAA1, B4GALT5, GIT2, NAA15, and RPIA) were significantly associated with SLE Disease Activity Index-2K (SLEDAI-2K) scores and 1-year flare risk, implicating key pathways such as B-cell receptor signaling and platelet degranulation. SAA1 demonstrated causal effects on flare-related clinical markers, including hemoglobin and red blood cell counts. A combined model integrating clinical and proteomic data achieved the highest predictive accuracy (AUC = 0.769), surpassing individual models. SAA1 was highlighted as a priority biomarker for rapid flare discrimination. Conclusion: The integration of proteomic and clinical data significantly improves flare prediction in Asian SLE patients. The identification of key proteins and their causal relationships with flare-related clinical markers provides valuable insights for proactive SLE management and personalized therapeutic approaches.