Associative Memories in the Feature Space

An autoassociative memory model is a function that, given a set of data points, takes as input an arbitrary vector and outputs the most similar data point from the memorized set. However, popular memory models fail to retrieve images even when the corruption is mild and easy to detect for a human evaluator. This is because similarities are evaluated in the raw pixel space, which does not contain any semantic information about the images. This problem can be easily solved by computing \emph{similarities} in an embedding space instead of the pixel space. We show that an effective way of computing such embeddings is via a network pretrained with a contrastive loss. As the dimension of embedding spaces is often significantly smaller than the pixel space, we also have a faster computation of similarity scores. We test this method on complex datasets such as CIFAR10 and STL10. An additional drawback of current models is the need of storing the whole dataset in the pixel space, which is often extremely large. We relax this condition and propose a class of memory models that only stores low-dimensional semantic embeddings, and uses them to retrieve similar, but not identical, memories. We demonstrate a proof of concept of this method on a simple task on the MNIST dataset.

Sequential Memory with Temporal Predictive Coding

Memorizing the temporal order of event sequences is critical for the survival of biological agents. However, the computational mechanism underlying sequential memory in the brain remains unclear. Inspired by neuroscience theories and recent successes in applying predictive coding (PC) to static memory tasks, in this work we propose a novel PC-based model for sequential memory, called temporal predictive coding (tPC). We show that our tPC models can memorize and retrieve sequential inputs accurately with a biologically plausible neural implementation. Importantly, our analytical study reveals that tPC can be viewed as a classical Asymmetric Hopfield Network (AHN) with an implicit statistical whitening process, which leads to more stable performance in sequential memory tasks of structured inputs. Moreover, we find that tPC with a multi-layer structure can encode context-dependent information, thus distinguishing between repeating elements appearing in a sequence, a computation attributed to the hippocampus. Our work establishes a possible computational mechanism underlying sequential memory in the brain that can also be theoretically interpreted using existing memory model frameworks.

Incremental Predictive Coding: A Parallel and Fully Automatic Learning Algorithm

Neuroscience-inspired models, such as predictive coding, have the potential to play an important role in the future of machine intelligence. However, they are not yet used in industrial applications due to some limitations, such as the lack of efficiency. In this work, we address this by proposing incremental predictive coding (iPC), a variation of the original framework derived from the incremental expectation maximization algorithm, where every operation can be performed in parallel without external control. We show both theoretically and empirically that iPC is much faster than the original algorithm originally developed by Rao and Ballard, while maintaining performance comparable to backpropagation in image classification tasks. This work impacts several areas, has general applications in computational neuroscience and machine learning, and specific applications in scenarios where automatization and parallelization are important, such as distributed computing and implementations of deep learning models on analog and neuromorphic chips.

A Theoretical Framework for Inference and Learning in Predictive Coding Networks

Predictive coding (PC) is an influential theory in computational neuroscience, which argues that the cortex forms unsupervised world models by implementing a hierarchical process of prediction error minimization. PC networks (PCNs) are trained in two phases. First, neural activities are updated to optimize the network's response to external stimuli. Second, synaptic weights are updated to consolidate this change in activity -- an algorithm called \emph{prospective configuration}. While previous work has shown how in various limits, PCNs can be found to approximate backpropagation (BP), recent work has demonstrated that PCNs operating in this standard regime, which does not approximate BP, nevertheless obtain competitive training and generalization performance to BP-trained networks while outperforming them on tasks such as online, few-shot, and continual learning, where brains are known to excel. Despite this promising empirical performance, little is understood theoretically about the properties and dynamics of PCNs in this regime. In this paper, we provide a comprehensive theoretical analysis of the properties of PCNs trained with prospective configuration. We first derive analytical results concerning the inference equilibrium for PCNs and a previously unknown close connection relationship to target propagation (TP). Secondly, we provide a theoretical analysis of learning in PCNs as a variant of generalized expectation-maximization and use that to prove the convergence of PCNs to critical points of the BP loss function, thus showing that deep PCNs can, in theory, achieve the same generalization performance as BP, while maintaining their unique advantages.

Backpropagation at the Infinitesimal Inference Limit of Energy-Based Models: Unifying Predictive Coding, Equilibrium Propagation, and Contrastive Hebbian Learning

How the brain performs credit assignment is a fundamental unsolved problem in neuroscience. Many `biologically plausible' algorithms have been proposed, which compute gradients that approximate those computed by backpropagation (BP), and which operate in ways that more closely satisfy the constraints imposed by neural circuitry. Many such algorithms utilize the framework of energy-based models (EBMs), in which all free variables in the model are optimized to minimize a global energy function. However, in the literature, these algorithms exist in isolation and no unified theory exists linking them together. Here, we provide a comprehensive theory of the conditions under which EBMs can approximate BP, which lets us unify many of the BP approximation results in the literature (namely, predictive coding, equilibrium propagation, and contrastive Hebbian learning) and demonstrate that their approximation to BP arises from a simple and general mathematical property of EBMs at free-phase equilibrium. This property can then be exploited in different ways with different energy functions, and these specific choices yield a family of BP-approximating algorithms, which both includes the known results in the literature and can be used to derive new ones.

Predictive Coding: Towards a Future of Deep Learning beyond Backpropagation?

The backpropagation of error algorithm used to train deep neural networks has been fundamental to the successes of deep learning. However, it requires sequential backward updates and non-local computations, which make it challenging to parallelize at scale and is unlike how learning works in the brain. Neuroscience-inspired learning algorithms, however, such as \emph{predictive coding}, which utilize local learning, have the potential to overcome these limitations and advance beyond current deep learning technologies. While predictive coding originated in theoretical neuroscience as a model of information processing in the cortex, recent work has developed the idea into a general-purpose algorithm able to train neural networks using only local computations. In this survey, we review works that have contributed to this perspective and demonstrate the close theoretical connections between predictive coding and backpropagation, as well as works that highlight the multiple advantages of using predictive coding models over backpropagation-trained neural networks. Specifically, we show the substantially greater flexibility of predictive coding networks against equivalent deep neural networks, which can function as classifiers, generators, and associative memories simultaneously, and can be defined on arbitrary graph topologies. Finally, we review direct benchmarks of predictive coding networks on machine learning classification tasks, as well as its close connections to control theory and applications in robotics.

Universal Hopfield Networks: A General Framework for Single-Shot Associative Memory Models

A large number of neural network models of associative memory have been proposed in the literature. These include the classical Hopfield networks (HNs), sparse distributed memories (SDMs), and more recently the modern continuous Hopfield networks (MCHNs), which possesses close links with self-attention in machine learning. In this paper, we propose a general framework for understanding the operation of such memory networks as a sequence of three operations: similarity, separation, and projection. We derive all these memory models as instances of our general framework with differing similarity and separation functions. We extend the mathematical framework of Krotov et al (2020) to express general associative memory models using neural network dynamics with only second-order interactions between neurons, and derive a general energy function that is a Lyapunov function of the dynamics. Finally, using our framework, we empirically investigate the capacity of using different similarity functions for these associative memory models, beyond the dot product similarity measure, and demonstrate empirically that Euclidean or Manhattan distance similarity metrics perform substantially better in practice on many tasks, enabling a more robust retrieval and higher memory capacity than existing models.

Learning on Arbitrary Graph Topologies via Predictive Coding

Training with backpropagation (BP) in standard deep learning consists of two main steps: a forward pass that maps a data point to its prediction, and a backward pass that propagates the error of this prediction back through the network. This process is highly effective when the goal is to minimize a specific objective function. However, it does not allow training on networks with cyclic or backward connections. This is an obstacle to reaching brain-like capabilities, as the highly complex heterarchical structure of the neural connections in the neocortex are potentially fundamental for its effectiveness. In this paper, we show how predictive coding (PC), a theory of information processing in the cortex, can be used to perform inference and learning on arbitrary graph topologies. We experimentally show how this formulation, called PC graphs, can be used to flexibly perform different tasks with the same network by simply stimulating specific neurons, and investigate how the topology of the graph influences the final performance. We conclude by comparing against simple baselines trained~with~BP.

Associative Memories via Predictive Coding

Associative memories in the brain receive and store patterns of activity registered by the sensory neurons, and are able to retrieve them when necessary. Due to their importance in human intelligence, computational models of associative memories have been developed for several decades now. They include autoassociative memories, which allow for storing data points and retrieving a stored data point $s$ when provided with a noisy or partial variant of $s$, and heteroassociative memories, able to store and recall multi-modal data. In this paper, we present a novel neural model for realizing associative memories, based on a hierarchical generative network that receives external stimuli via sensory neurons. This model is trained using predictive coding, an error-based learning algorithm inspired by information processing in the cortex. To test the capabilities of this model, we perform multiple retrieval experiments from both corrupted and incomplete data points. In an extensive comparison, we show that this new model outperforms in retrieval accuracy and robustness popular associative memory models, such as autoencoders trained via backpropagation, and modern Hopfield networks. In particular, in completing partial data points, our model achieves remarkable results on natural image datasets, such as ImageNet, with a surprisingly high accuracy, even when only a tiny fraction of pixels of the original images is presented. Furthermore, we show that this method is able to handle multi-modal data, retrieving images from descriptions, and vice versa. We conclude by discussing the possible impact of this work in the neuroscience community, by showing that our model provides a plausible framework to study learning and retrieval of memories in the brain, as it closely mimics the behavior of the hippocampus as a memory index and generative model.

Embedding digital chronotherapy into medical devices -- A canine case study in controlling status epilepticus through multi-scale rhythmic brain stimulation

Circadian and other physiological rhythms play a key role in both normal homeostasis and disease processes. Such is the case of circadian and infradian seizure patterns observed in epilepsy. However, these rhythms are not fully exploited in the design of active implantable medical devices. In this paper we explore a new implantable stimulator that implements chronotherapy as a feedforward input to supplement both open-loop and closed-loop methods. This integrated algorithm allows for stimulation to be adjusted to the ultradian, circadian, and infradian patterns observed in patients through slowly-varying temporal adjustments of stimulation and algorithm sub-components, while also enabling adaption of stimulation based on immediate physiological needs such as a breakthrough seizure or change of posture. Embedded physiological sensors in the stimulator can be used to refine the baseline stimulation circadian pattern as a "digital zeitgeber". This algorithmic approach is tested on a canine with severe drug-resistant idiopathic generalized epilepsy exhibiting a characteristic diurnal pattern correlated with sleep-wake cycles. Prior to implantation, the canine's cluster seizures evolved to status epilepticus (SE) and required emergency pharmacological intervention. The cranially-mounted system was fully-implanted bilaterally into the centromedian nucleus of the thalamus. Using combinations of time-based modulation, thalamocortical rhythm-specific tuning of frequency parameters, and fast-adaptive modes based on activity, the canine has experienced no further SE events post-implant at the time of writing (7 months), and no significant clusters are observed any longer. The use of digitally-enabled chronotherapy as a feedforward signal to augment adaptive neurostimulators could prove a useful algorithmic method where sensitivity to temporal patterns are characteristics of the disease state.