EpiBench: Can LLMs Understand Epitopes for Antibody Drug Discovery?

Epitopes determine where antibodies bind antigens and shape downstream therapeutic properties such as functional blockade and escape resistance, making epitope understanding central to antibody drug discovery. Although large language models (LLMs) have shown strong biomedical reasoning ability, it remains unclear whether they can infer epitope information directly from antigen and antibody sequences. Existing epitope resources typically focus on isolated prediction tasks or rely on specialized structural settings, while general protein benchmarks do not evaluate epitope-centered decisions across the antibody development workflow. To address this gap, we introduce EpiBench, a closed-book, sequence-based, and automatically scorable benchmark for evaluating epitope reasoning in LLMs. EpiBench contains 1,609 curated samples grounded in structural antibody--antigen contacts, curated functional B-cell assays, and deep mutational scanning escape measurements. It covers five connected tasks: targetable region discovery, antibody-conditioned epitope identification, epitope binning, functional epitope assessment, and antibody escape assessment, with controlled sampling to reduce shortcut-based evaluation artifacts. We evaluate nine general-purpose LLMs and analyze their behavior through task-specific baselines, antigen length stratification, explicit-reasoning comparison, and failure-mode inspection. The results show that current LLMs capture partial epitope-related signals but remain limited in antibody-specific sequence grounding, long-context residue localization, and biologically grounded reasoning. Therefore, EpiBench provides a diagnostic testbed for measuring and improving sequence-aware biomedical LLMs toward reliable LLM-assisted antibody discovery.

Rank-Then-Score: Enhancing Large Language Models for Automated Essay Scoring

In recent years, large language models (LLMs) achieve remarkable success across a variety of tasks. However, their potential in the domain of Automated Essay Scoring (AES) remains largely underexplored. Moreover, compared to English data, the methods for Chinese AES is not well developed. In this paper, we propose Rank-Then-Score (RTS), a fine-tuning framework based on large language models to enhance their essay scoring capabilities. Specifically, we fine-tune the ranking model (Ranker) with feature-enriched data, and then feed the output of the ranking model, in the form of a candidate score set, with the essay content into the scoring model (Scorer) to produce the final score. Experimental results on two benchmark datasets, HSK and ASAP, demonstrate that RTS consistently outperforms the direct prompting (Vanilla) method in terms of average QWK across all LLMs and datasets, and achieves the best performance on Chinese essay scoring using the HSK dataset.