Diff-FMT: Diffusion Models for Fluorescence Molecular Tomography

Fluorescence molecular tomography (FMT) is a real-time, noninvasive optical imaging technology that plays a significant role in biomedical research. Nevertheless, the ill-posedness of the inverse problem poses huge challenges in FMT reconstructions. Previous various deep learning algorithms have been extensively explored to address the critical issues, but they remain faces the challenge of high data dependency with poor image quality. In this paper, we, for the first time, propose a FMT reconstruction method based on a denoising diffusion probabilistic model (DDPM), termed Diff-FMT, which is capable of obtaining high-quality reconstructed images from noisy images. Specifically, we utilize the noise addition mechanism of DDPM to generate diverse training samples. Through the step-by-step probability sampling mechanism in the inverse process, we achieve fine-grained reconstruction of the image, avoiding issues such as loss of image detail that can occur with end-to-end deep-learning methods. Additionally, we introduce the fluorescence signals as conditional information in the model training to sample a reconstructed image that is highly consistent with the input fluorescence signals from the noisy images. Numerous experimental results show that Diff-FMT can achieve high-resolution reconstruction images without relying on large-scale datasets compared with other cutting-edge algorithms.