MindGap: A Conversational AI Framework for Upstream Neuroplastic Intervention in Post-Traumatic Stress Disorder

Post-Traumatic Stress Disorder (PTSD) is fundamentally a neuroplastic problem traumatic contact events encode over-reactive neural pathways through Hebbian long-term potentiation, producing hair-triggered amygdala-HPA stress cascades that fire before conscious awareness can intercept them. Existing therapeutic approaches, prolonged exposure, EMDR, cognitive behavioural therapy, operate predominantly downstream of the reactive cascade, teaching patients to tolerate or reframe distress after it has arisen. While clinically valuable, these suppression-based approaches do not produce the upstream pathway dissolution that constitutes lasting structural neural reorganisation. This paper proposes MindGap, a privacy-preserving on-device conversational AI framework that delivers structured neuroplastic rehabilitation for PTSD through the practice of dependent origination, a Buddhist psychological framework that identifies the precise moment between the pre-cognitive affective signal and the reactive elaboration that follows as the site of therapeutic intervention. MindGap guides patients through three progressive layers of observation at this feeling tone gap: noticing the bare affective signal before reactive elaboration, recognising it as self-arising rather than caused by the stimulus, and recognising the conditioned implicit belief beneath the feeling. Each layer corresponds to progressively deeper prefrontal regulatory engagement and progressively deeper long-term depression-mediated weakening of the reactive pathway, producing genuine upstream dissolution rather than downstream suppression. Running entirely on-device with no data egress, MindGap delivers daily calibrated exposure sessions through a fine-tuned lightweight large language model, making it deployable in sensitive clinical and military contexts where cloud-based solutions are not permitted.

Flowr -- Scaling Up Retail Supply Chain Operations Through Agentic AI in Large Scale Supermarket Chains

Retail supply chain operations in supermarket chains involve continuous, high-volume manual workflows spanning demand forecasting, procurement, supplier coordination, and inventory replenishment, processes that are repetitive, decision-intensive, and difficult to scale without significant human effort. Despite growing investment in data analytics, the decision-making and coordination layers of these workflows remain predominantly manual, reactive, and fragmented across outlets, distribution centers, and supplier networks. This paper introduces Flowr, a novel agentic AI framework for automating end-to-end retail supply chain workflows in large-scale supermarket operations. Flowr systematically decomposes manual supply chain operations into specialized AI agents, each responsible for a clearly defined cognitive role, enabling automation of processes previously dependent on continuous human coordination. To ensure task accuracy and adherence to responsible AI principles, the framework employs a consortium of fine-tuned, domain-specialized large language models coordinated by a central reasoning LLM. Central to the framework is a human-in-the-loop orchestration model in which supply chain managers supervise and intervene across workflow stages via a Model Context Protocol (MCP)-enabled interface, preserving accountability and organizational control. Evaluation demonstrates that Flowr significantly reduces manual coordination overhead, improves demand-supply alignment, and enables proactive exception handling at a scale unachievable through manual processes. The framework was validated in collaboration with a large-scale supermarket chain and is domain-independent, offering a generalizable blueprint for agentic AI-driven supply chain automation across large-scale enterprise settings.