Federated Learning for MRI-based BrainAGE: a multicenter study on post-stroke functional outcome prediction

$\textbf{Objective:}$ Brain-predicted age difference (BrainAGE) is a neuroimaging biomarker reflecting brain health. However, training robust BrainAGE models requires large datasets, often restricted by privacy concerns. This study evaluates the performance of federated learning (FL) for BrainAGE estimation in ischemic stroke patients treated with mechanical thrombectomy, and investigates its association with clinical phenotypes and functional outcomes. $\textbf{Methods:}$ We used FLAIR brain images from 1674 stroke patients across 16 hospital centers. We implemented standard machine learning and deep learning models for BrainAGE estimates under three data management strategies: centralized learning (pooled data), FL (local training at each site), and single-site learning. We reported prediction errors and examined associations between BrainAGE and vascular risk factors (e.g., diabetes mellitus, hypertension, smoking), as well as functional outcomes at three months post-stroke. Logistic regression evaluated BrainAGE's predictive value for these outcomes, adjusting for age, sex, vascular risk factors, stroke severity, time between MRI and arterial puncture, prior intravenous thrombolysis, and recanalisation outcome. $\textbf{Results:}$ While centralized learning yielded the most accurate predictions, FL consistently outperformed single-site models. BrainAGE was significantly higher in patients with diabetes mellitus across all models. Comparisons between patients with good and poor functional outcomes, and multivariate predictions of these outcomes showed the significance of the association between BrainAGE and post-stroke recovery. $\textbf{Conclusion:}$ FL enables accurate age predictions without data centralization. The strong association between BrainAGE, vascular risk factors, and post-stroke recovery highlights its potential for prognostic modeling in stroke care.

TAMIS: Tailored Membership Inference Attacks on Synthetic Data

Membership Inference Attacks (MIA) enable to empirically assess the privacy of a machine learning algorithm. In this paper, we propose TAMIS, a novel MIA against differentially-private synthetic data generation methods that rely on graphical models. This attack builds upon MAMA-MIA, a recently-published state-of-the-art method. It lowers its computational cost and requires less attacker knowledge. Our attack is the product of a two-fold improvement. First, we recover the graphical model having generated a synthetic dataset by using solely that dataset, rather than shadow-modeling over an auxiliary one. This proves less costly and more performant. Second, we introduce a more mathematically-grounded attack score, that provides a natural threshold for binary predictions. In our experiments, TAMIS achieves better or similar performance as MAMA-MIA on replicas of the SNAKE challenge.