ArteryX: Advancing Brain Artery Feature Extraction with Vessel-Fused Networks and a Robust Validation Framework

Cerebrovascular pathology significantly contributes to cognitive decline and neurological disorders, underscoring the need for advanced tools to assess vascular integrity. Three-dimensional Time-of-Flight Magnetic Resonance Angiography (3D TOF MRA) is widely used to visualize cerebral vasculature, however, clinical evaluations generally focus on major arterial abnormalities, overlooking quantitative metrics critical for understanding subtle vascular changes. Existing methods for extracting structural, geometrical and morphological arterial features from MRA - whether manual or automated - face challenges including user-dependent variability, steep learning curves, and lack of standardized quantitative validations. We propose a novel semi-supervised artery evaluation framework, named ArteryX, a MATLAB-based toolbox that quantifies vascular features with high accuracy and efficiency, achieving processing times ~10-15 minutes per subject at 0.5 mm resolution with minimal user intervention. ArteryX employs a vessel-fused network based landmarking approach to reliably track and manage tracings, effectively addressing the issue of dangling/disconnected vessels. Validation on human subjects with cerebral small vessel disease demonstrated its improved sensitivity to subtle vascular changes and better performance than an existing semi-automated method. Importantly, the ArteryX toolbox enables quantitative feature validation by integrating an in-vivo like artery simulation framework utilizing vessel-fused graph nodes and predefined ground-truth features for specific artery types. Thus, the ArteryX framework holds promise for benchmarking feature extraction toolboxes and for seamless integration into clinical workflows, enabling early detection of cerebrovascular pathology and standardized comparisons across patient cohorts to advance understanding of vascular contributions to brain health.

FairAIED: Navigating Fairness, Bias, and Ethics in Educational AI Applications

The integration of Artificial Intelligence (AI) into education has transformative potential, providing tailored learning experiences and creative instructional approaches. However, the inherent biases in AI algorithms hinder this improvement by unintentionally perpetuating prejudice against specific demographics, especially in human-centered applications like education. This survey delves deeply into the developing topic of algorithmic fairness in educational contexts, providing a comprehensive evaluation of the diverse literature on fairness, bias, and ethics in AI-driven educational applications. It identifies the common forms of biases, such as data-related, algorithmic, and user-interaction, that fundamentally undermine the accomplishment of fairness in AI teaching aids. By outlining existing techniques for mitigating these biases, ranging from varied data gathering to algorithmic fairness interventions, the survey emphasizes the critical role of ethical considerations and legal frameworks in shaping a more equitable educational environment. Furthermore, it guides readers through the complexities of fairness measurements, methods, and datasets, shedding light on the way to bias reduction. Despite these gains, this survey highlights long-standing issues, such as achieving a balance between fairness and accuracy, as well as the need for diverse datasets. Overcoming these challenges and ensuring the ethical and fair use of AI's promise in education call for a collaborative, interdisciplinary approach.