Addressing Data Heterogeneity in Federated Learning of Cox Proportional Hazards Models

The diversity in disease profiles and therapeutic approaches between hospitals and health professionals underscores the need for patient-centric personalized strategies in healthcare. Alongside this, similarities in disease progression across patients can be utilized to improve prediction models in survival analysis. The need for patient privacy and the utility of prediction models can be simultaneously addressed in the framework of Federated Learning (FL). This paper outlines an approach in the domain of federated survival analysis, specifically the Cox Proportional Hazards (CoxPH) model, with a specific focus on mitigating data heterogeneity and elevating model performance. We present an FL approach that employs feature-based clustering to enhance model accuracy across synthetic datasets and real-world applications, including the Surveillance, Epidemiology, and End Results (SEER) database. Furthermore, we consider an event-based reporting strategy that provides a dynamic approach to model adaptation by responding to local data changes. Our experiments show the efficacy of our approach and discuss future directions for a practical application of FL in healthcare.

Using Geographic Location-based Public Health Features in Survival Analysis

Time elapsed till an event of interest is often modeled using the survival analysis methodology, which estimates a survival score based on the input features. There is a resurgence of interest in developing more accurate prediction models for time-to-event prediction in personalized healthcare using modern tools such as neural networks. Higher quality features and more frequent observations improve the predictions for a patient, however, the impact of including a patient's geographic location-based public health statistics on individual predictions has not been studied. This paper proposes a complementary improvement to survival analysis models by incorporating public health statistics in the input features. We show that including geographic location-based public health information results in a statistically significant improvement in the concordance index evaluated on the Surveillance, Epidemiology, and End Results (SEER) dataset containing nationwide cancer incidence data. The improvement holds for both the standard Cox proportional hazards model and the state-of-the-art Deep Survival Machines model. Our results indicate the utility of geographic location-based public health features in survival analysis.