Data-Driven Soft Labeling Scales DNA Read Classification to Whole-Body Cell-Type Deconvolution

Cell-type deconvolution, the task of estimating the proportions of constituent cell types in a heterogeneous biological sample, is a core problem in computational biology. Methods that rely on epigenetic marks such as DNA methylation typically operate on aggregated methylation estimates, discarding the pattern-level information carried by individual DNA reads. Existing read-level approaches that exploit this information are scarce, and all remain restricted to few-class settings; scaling them further is an open problem because, at scale, non-discriminative reads dominate and hard labels conflict with the many-to-many mapping between methylation patterns and cell types, preventing classifier convergence. To overcome this, we propose data-driven soft labels that estimate the conditional cell-type distribution for each read, and integrate this scheme into Syto, a new modular framework for read-level classification-based deconvolution. On a whole-body atlas of 39 human cell types, Syto reduces MSE by 2.56$\times$ over SoTA, with gains transferring to an out-of-distribution dataset spanning 16 tissues. Syto lays the foundation for modeling increasingly large cell-type panels, with improved applications in biology and healthcare. The proposed soft-labeling scheme is further translatable to any setting with a many-to-many signal-to-label mapping.

Dynamic Scheduling for Enhanced Performance in RIS-assisted Cooperative Network with Interference

Reconfigurable Intelligent Surfaces (RIS) have emerged as transformative technologies, enhancing spectral efficiency and improving interference management in multi-user cooperative communications. This paper investigates the integration of RIS with Flexible-Duplex (FlexD) communication, featuring dynamic scheduling capabilities, to mitigate unintended external interference in multi-user wireless networks. By leveraging the reconfigurability of RIS and dynamic scheduling, we propose a user-pair selection scheme to maximize system throughput when full channel state information (CSI) of interference is unavailable. We develop a mathematical framework to evaluate the throughput outage probability when RIS introduces spatial correlation. The derived analytical results are used for asymptotic analysis, providing insights into dynamic user scheduling under interference based on statistical channel knowledge. Finally, we compare FlexD with traditional Full Duplex (FD) and Half Duplex (HD) systems against RIS-assisted FlexD. Our results show FlexD's superior throughput enhancement, energy efficiency and data management capability in interference-affected networks, typical in current and next-generation cooperative wireless applications like cellular and vehicular communications.

Gaussian random field approximation via Stein's method with applications to wide random neural networks

We derive upper bounds on the Wasserstein distance ($W_1$), with respect to $\sup$-norm, between any continuous $\mathbb{R}^d$ valued random field indexed by the $n$-sphere and the Gaussian, based on Stein's method. We develop a novel Gaussian smoothing technique that allows us to transfer a bound in a smoother metric to the $W_1$ distance. The smoothing is based on covariance functions constructed using powers of Laplacian operators, designed so that the associated Gaussian process has a tractable Cameron-Martin or Reproducing Kernel Hilbert Space. This feature enables us to move beyond one dimensional interval-based index sets that were previously considered in the literature. Specializing our general result, we obtain the first bounds on the Gaussian random field approximation of wide random neural networks of any depth and Lipschitz activation functions at the random field level. Our bounds are explicitly expressed in terms of the widths of the network and moments of the random weights. We also obtain tighter bounds when the activation function has three bounded derivatives.