Reconfigurable Intelligent Surfaces (RIS) have emerged as transformative technologies, enhancing spectral efficiency and improving interference management in multi-user cooperative communications. This paper investigates the integration of RIS with Flexible-Duplex (FlexD) communication, featuring dynamic scheduling capabilities, to mitigate unintended external interference in multi-user wireless networks. By leveraging the reconfigurability of RIS and dynamic scheduling, we propose a user-pair selection scheme to maximize system throughput when full channel state information (CSI) of interference is unavailable. We develop a mathematical framework to evaluate the throughput outage probability when RIS introduces spatial correlation. The derived analytical results are used for asymptotic analysis, providing insights into dynamic user scheduling under interference based on statistical channel knowledge. Finally, we compare FlexD with traditional Full Duplex (FD) and Half Duplex (HD) systems against RIS-assisted FlexD. Our results show FlexD's superior throughput enhancement, energy efficiency and data management capability in interference-affected networks, typical in current and next-generation cooperative wireless applications like cellular and vehicular communications.