Decoding inner speech from the brain signal via hybridisation of fMRI and EEG data is explored to investigate the performance benefits over unimodal models. Two different bimodal fusion approaches are examined: concatenation of probability vectors output from unimodal fMRI and EEG machine learning models, and data fusion with feature engineering. Same task inner speech data are recorded from four participants, and different processing strategies are compared and contrasted to previously-employed hybridisation methods. Data across participants are discovered to encode different underlying structures, which results in varying decoding performances between subject-dependent fusion models. Decoding performance is demonstrated as improved when pursuing bimodal fMRI-EEG fusion strategies, if the data show underlying structure.
Current state-of-the-art reconstruction for quantitative tissue maps from fast, compressive, Magnetic Resonance Fingerprinting (MRF), use supervised deep learning, with the drawback of requiring high-fidelity ground truth tissue map training data which is limited. This paper proposes NonLinear Equivariant Imaging (NLEI), a self-supervised learning approach to eliminate the need for ground truth for deep MRF image reconstruction. NLEI extends the recent Equivariant Imaging framework to nonlinear inverse problems such as MRF. Only fast, compressed-sampled MRF scans are used for training. NLEI learns tissue mapping using spatiotemporal priors: spatial priors are obtained from the invariance of MRF data to a group of geometric image transformations, while temporal priors are obtained from a nonlinear Bloch response model approximated by a pre-trained neural network. Tested retrospectively on two acquisition settings, we observe that NLEI (self-supervised learning) closely approaches the performance of supervised learning, despite not using ground truth during training.
Current spatiotemporal deep learning approaches to Magnetic Resonance Fingerprinting (MRF) build artefact-removal models customised to a particular k-space subsampling pattern which is used for fast (compressed) acquisition. This may not be useful when the acquisition process is unknown during training of the deep learning model and/or changes during testing time. This paper proposes an iterative deep learning plug-and-play reconstruction approach to MRF which is adaptive to the forward acquisition process. Spatiotemporal image priors are learned by an image denoiser i.e. a Convolutional Neural Network (CNN), trained to remove generic white gaussian noise (not a particular subsampling artefact) from data. This CNN denoiser is then used as a data-driven shrinkage operator within the iterative reconstruction algorithm. This algorithm with the same denoiser model is then tested on two simulated acquisition processes with distinct subsampling patterns. The results show consistent de-aliasing performance against both acquisition schemes and accurate mapping of tissues' quantitative bio-properties. Software available: https://github.com/ketanfatania/QMRI-PnP-Recon-POC
Magnetic Resonance Fingerprinting (MRF) has emerged as a promising quantitative MR imaging approach. Deep learning methods have been proposed for MRF and demonstrated improved performance over classical compressed sensing algorithms. However many of these end-to-end models are physics-free, while consistency of the predictions with respect to the physical forward model is crucial for reliably solving inverse problems. To address this, recently [1] proposed a proximal gradient descent framework that directly incorporates the forward acquisition and Bloch dynamic models within an unrolled learning mechanism. However, [1] only evaluated the unrolled model on synthetic data using Cartesian sampling trajectories. In this paper, as a complementary to [1], we investigate other choices of encoders to build the proximal neural network, and evaluate the deep unrolling algorithm on real accelerated MRF scans with non-Cartesian k-space sampling trajectories.
We propose a novel numerical approach to separate multiple tissue compartments in image voxels and to estimate quantitatively their nuclear magnetic resonance (NMR) properties and mixture fractions, given magnetic resonance fingerprinting (MRF) measurements. The number of tissues, their types or quantitative properties are not a-priori known, but the image is assumed to be composed of sparse compartments with linearly mixed Bloch magnetisation responses within voxels. Fine-grid discretisation of the multi-dimensional NMR properties creates large and highly coherent MRF dictionaries that can challenge scalability and precision of the numerical methods for (discrete) sparse approximation. To overcome these issues, we propose an off-the-grid approach equipped with an extended notion of the sparse group lasso regularisation for sparse approximation using continuous (non-discretised) Bloch response models. Further, the nonlinear and non-analytical Bloch responses are approximated by a neural network, enabling efficient back-propagation of the gradients through the proposed algorithm. Tested on simulated and in-vivo healthy brain MRF data, we demonstrate effectiveness of the proposed scheme compared to the baseline multicompartment MRF methods.
Consistency of the predictions with respect to the physical forward model is pivotal for reliably solving inverse problems. This consistency is mostly un-controlled in the current end-to-end deep learning methodologies proposed for the Magnetic Resonance Fingerprinting (MRF) problem. To address this, we propose ProxNet, a learned proximal gradient descent framework that directly incorporates the forward acquisition and Bloch dynamic models within a recurrent learning mechanism. The ProxNet adopts a compact neural proximal model for de-aliasing and quantitative inference, that can be flexibly trained on scarce MRF training datasets. Our numerical experiments show that the ProxNet can achieve a superior quantitative inference accuracy, much smaller storage requirement, and a comparable runtime to the recent deep learning MRF baselines, while being much faster than the dictionary matching schemes. Code has been released at https://github.com/edongdongchen/PGD-Net.
We propose a dictionary-matching-free pipeline for multi-parametric quantitative MRI image computing. Our approach has two stages based on compressed sensing reconstruction and deep learned quantitative inference. The reconstruction phase is convex and incorporates efficient spatiotemporal regularisations within an accelerated iterative shrinkage algorithm. This minimises the under-sampling (aliasing) artefacts from aggressively short scan times. The learned quantitative inference phase is purely trained on physical simulations (Bloch equations) that are flexible for producing rich training samples. We propose a deep and compact auto-encoder network with residual blocks in order to embed Bloch manifold projections through multiscale piecewise affine approximations, and to replace the nonscalable dictionary-matching baseline. Tested on a number of datasets we demonstrate effectiveness of the proposed scheme for recovering accurate and consistent quantitative information from novel and aggressively subsampled 2D/3D quantitative MRI acquisition protocols.
In this work we investigate the practicality of stochastic gradient descent and recently introduced variants with variance-reduction techniques in imaging inverse problems. Such algorithms have been shown in the machine learning literature to have optimal complexities in theory, and provide great improvement empirically over the deterministic gradient methods. Surprisingly, in some tasks such as image deblurring, many of such methods fail to converge faster than the accelerated deterministic gradient methods, even in terms of epoch counts. We investigate this phenomenon and propose a theory-inspired mechanism for the practitioners to efficiently characterize whether it is beneficial for an inverse problem to be solved by stochastic optimization techniques or not. Using standard tools in numerical linear algebra, we derive conditions on the spectral structure of the inverse problem for being a suitable application of stochastic gradient methods. Particularly, we show that, for an imaging inverse problem, if and only if its Hessain matrix has a fast-decaying eigenspectrum, then the stochastic gradient methods can be more advantageous than deterministic methods for solving such a problem. Our results also provide guidance on choosing appropriately the partition minibatch schemes, showing that a good minibatch scheme typically has relatively low correlation within each of the minibatches. Finally, we propose an accelerated primal-dual SGD algorithm in order to tackle another key bottleneck of stochastic optimization which is the heavy computation of proximal operators. The proposed method has fast convergence rate in practice, and is able to efficiently handle non-smooth regularization terms which are coupled with linear operators.