Hybridized Convolutional Neural Networks and Long Short-Term Memory for Improved Alzheimer's Disease Diagnosis from MRI Scans

Brain-related diseases are more sensitive than other diseases due to several factors, including the complexity of surgical procedures, high costs, and other challenges. Alzheimer's disease is a common brain disorder that causes memory loss and the shrinking of brain cells. Early detection is critical for providing proper treatment to patients. However, identifying Alzheimer's at an early stage using manual scanning of CT or MRI scans is challenging. Therefore, researchers have delved into the exploration of computer-aided systems, employing Machine Learning and Deep Learning methodologies, which entail the training of datasets to detect Alzheimer's disease. This study aims to present a hybrid model that combines a CNN model's feature extraction capabilities with an LSTM model's detection capabilities. This study has applied the transfer learning called VGG16 in the hybrid model to extract features from MRI images. The LSTM detects features between the convolution layer and the fully connected layer. The output layer of the fully connected layer uses the softmax function. The training of the hybrid model involved utilizing the ADNI dataset. The trial findings revealed that the model achieved a level of accuracy of 98.8%, a sensitivity rate of 100%, and a specificity rate of 76%. The proposed hybrid model outperforms its contemporary CNN counterparts, showcasing a superior performance.

Exploring Gene Regulatory Interaction Networks and predicting therapeutic molecules for Hypopharyngeal Cancer and EGFR-mutated lung adenocarcinoma

With the advent of Information technology, the Bioinformatics research field is becoming increasingly attractive to researchers and academicians. The recent development of various Bioinformatics toolkits has facilitated the rapid processing and analysis of vast quantities of biological data for human perception. Most studies focus on locating two connected diseases and making some observations to construct diverse gene regulatory interaction networks, a forerunner to general drug design for curing illness. For instance, Hypopharyngeal cancer is a disease that is associated with EGFR-mutated lung adenocarcinoma. In this study, we select EGFR-mutated lung adenocarcinoma and Hypopharyngeal cancer by finding the Lung metastases in hypopharyngeal cancer. To conduct this study, we collect Mircorarray datasets from GEO (Gene Expression Omnibus), an online database controlled by NCBI. Differentially expressed genes, common genes, and hub genes between the selected two diseases are detected for the succeeding move. Our research findings have suggested common therapeutic molecules for the selected diseases based on 10 hub genes with the highest interactions according to the degree topology method and the maximum clique centrality (MCC). Our suggested therapeutic molecules will be fruitful for patients with those two diseases simultaneously.

MLSTL-WSN: Machine Learning-based Intrusion Detection using SMOTETomek in WSNs

Wireless Sensor Networks (WSNs) play a pivotal role as infrastructures, encompassing both stationary and mobile sensors. These sensors self-organize and establish multi-hop connections for communication, collectively sensing, gathering, processing, and transmitting data about their surroundings. Despite their significance, WSNs face rapid and detrimental attacks that can disrupt functionality. Existing intrusion detection methods for WSNs encounter challenges such as low detection rates, computational overhead, and false alarms. These issues stem from sensor node resource constraints, data redundancy, and high correlation within the network. To address these challenges, we propose an innovative intrusion detection approach that integrates Machine Learning (ML) techniques with the Synthetic Minority Oversampling Technique Tomek Link (SMOTE-TomekLink) algorithm. This blend synthesizes minority instances and eliminates Tomek links, resulting in a balanced dataset that significantly enhances detection accuracy in WSNs. Additionally, we incorporate feature scaling through standardization to render input features consistent and scalable, facilitating more precise training and detection. To counteract imbalanced WSN datasets, we employ the SMOTE-Tomek resampling technique, mitigating overfitting and underfitting issues. Our comprehensive evaluation, using the WSN Dataset (WSN-DS) containing 374,661 records, identifies the optimal model for intrusion detection in WSNs. The standout outcome of our research is the remarkable performance of our model. In binary, it achieves an accuracy rate of 99.78% and in multiclass, it attains an exceptional accuracy rate of 99.92%. These findings underscore the efficiency and superiority of our proposal in the context of WSN intrusion detection, showcasing its effectiveness in detecting and mitigating intrusions in WSNs.