Molecular ISAC via Markov State-Space Modeling: Joint Distance Sensing and Data Detection

This paper develops a molecular integrated sensing and communication (ISAC) framework that exploits the same molecular observations for physical-parameter sensing and data detection. As a representative instantiation, we consider a microfluidic molecular communication (MC) channel and study transmitter--receiver (TX--RX) distance sensing, where the distance affects the propagation delay, transient response, and inter-symbol interference structure. A distance-parameterized Markov state--space model is established to obtain distance-dependent channel impulse responses and a block observation model for on-off keying signaling. Based on this model, we design a pilot-assisted low-complexity receiver that combines distance initialization, decision-feedback equalization (DFE), and iterative joint refinement. Numerical results show accurate distance sensing and improved bit error ratio (BER), demonstrating the mutual benefit between sensing and communication and highlighting microfluidic MC as a representative platform for molecular ISAC.

Markov State--Space Modeling and Channel Characterization for DNA-Based Molecular Communication

In this paper, we study DNA-based molecular communication with microarray-style reception under reversible hybridization, where the bound-state observation exhibits both inter-symbol interference and colored counting noise. To capture these effects in a communication-oriented form, we develop a Markov state-space framework based on a voxelized reaction--diffusion model, in which a block-structured transition matrix describes molecular transport and binding/unbinding dynamics. For the microarray specialization, this representation yields the channel impulse response, the equilibrium gain, and a settling-time-based characterization of the effective channel memory. Building on the resulting symbol-rate observation model for on--off keying, we derive a grouped-binomial counting model and obtain a closed-form expression for the covariance of the counting noise. Based on these statistics, we further develop a differential-threshold detector and a finite-memory decision-feedback equalizer. Numerical results validate the theoretical correlation behavior and show that the relative performance of the proposed receivers depends strongly on the channel-memory regime.

Modulation, ISI, and Detection for Langmuir Adsorption-Based Microfluidic Molecular Communication

This paper studies microfluidic molecular communication receivers with finite-capacity Langmuir adsorption driven by an effective surface concentration. In the reaction-limited regime, we derive a closed-form single-pulse response kernel and a symbol-rate recursion for on-off keying that explicitly exposes channel memory and inter-symbol interference. We further develop short-pulse and long-pulse approximations, revealing an interference asymmetry in the long-pulse regime due to saturation. To account for stochasticity, we adopt a finite-receptor binomial counting model, employ pulse-end sampling, and propose a low-complexity midpoint-threshold detector that reduces to a fixed threshold when interference is negligible. Numerical results corroborate the proposed characterization and quantify detection performance versus pulse and symbol durations.