MADPOT: Medical Anomaly Detection with CLIP Adaptation and Partial Optimal Transport

Medical anomaly detection (AD) is challenging due to diverse imaging modalities, anatomical variations, and limited labeled data. We propose a novel approach combining visual adapters and prompt learning with Partial Optimal Transport (POT) and contrastive learning (CL) to improve CLIP's adaptability to medical images, particularly for AD. Unlike standard prompt learning, which often yields a single representation, our method employs multiple prompts aligned with local features via POT to capture subtle abnormalities. CL further enforces intra-class cohesion and inter-class separation. Our method achieves state-of-the-art results in few-shot, zero-shot, and cross-dataset scenarios without synthetic data or memory banks. The code is available at https://github.com/mahshid1998/MADPOT.

Memory-Efficient 3D High-Resolution Medical Image Synthesis Using CRF-Guided GANs

Generative Adversarial Networks (GANs) have many potential medical imaging applications. Due to the limited memory of Graphical Processing Units (GPUs), most current 3D GAN models are trained on low-resolution medical images, these models cannot scale to high-resolution or are susceptible to patchy artifacts. In this work, we propose an end-to-end novel GAN architecture that uses Conditional Random field (CRF) to model dependencies so that it can generate consistent 3D medical Images without exploiting memory. To achieve this purpose, the generator is divided into two parts during training, the first part produces an intermediate representation and CRF is applied to this intermediate representation to capture correlations. The second part of the generator produces a random sub-volume of image using a subset of the intermediate representation. This structure has two advantages: first, the correlations are modeled by using the features that the generator is trying to optimize. Second, the generator can generate full high-resolution images during inference. Experiments on Lung CTs and Brain MRIs show that our architecture outperforms state-of-the-art while it has lower memory usage and less complexity.