Learning Reduced-Order Models for Cardiovascular Simulations with Graph Neural Networks

Reduced-order models based on physics are a popular choice in cardiovascular modeling due to their efficiency, but they may experience reduced accuracy when working with anatomies that contain numerous junctions or pathological conditions. We develop one-dimensional reduced-order models that simulate blood flow dynamics using a graph neural network trained on three-dimensional hemodynamic simulation data. Given the initial condition of the system, the network iteratively predicts the pressure and flow rate at the vessel centerline nodes. Our numerical results demonstrate the accuracy and generalizability of our method in physiological geometries comprising a variety of anatomies and boundary conditions. Our findings demonstrate that our approach can achieve errors below 2% and 3% for pressure and flow rate, respectively, provided there is adequate training data. As a result, our method exhibits superior performance compared to physics-based one-dimensional models, while maintaining high efficiency at inference time.

Data driven approximation of parametrized PDEs by Reduced Basis and Neural Networks

We are interested in the approximation of partial differential equations with a data-driven approach based on the reduced basis method and machine learning. We suppose that the phenomenon of interest can be modeled by a parametrized partial differential equation, but that the value of the physical parameters is unknown or difficult to be directly measured. Our method allows to estimate fields of interest, for instance temperature of a sample of material or velocity of a fluid, given data at a handful of points in the domain. We propose to accomplish this task with a neural network embedding a reduced basis solver as exotic activation function in the last layer. The reduced basis solver accounts for the underlying physical phenomenonon and it is constructed from snapshots obtained from randomly selected values of the physical parameters during an expensive offline phase. The same full order solutions are then employed for the training of the neural network. As a matter of fact, the chosen architecture resembles an asymmetric autoencoder in which the decoder is the reduced basis solver and as such it does not contain trainable parameters. The resulting latent space of our autoencoder includes parameter-dependent quantities feeding the reduced basis solver, which -- depending on the considered partial differential equation -- are the values of the physical parameters themselves or the affine decomposition coefficients of the differential operators.