A Statistical Learning Take on the Concordance Index for Survival Analysis

The introduction of machine learning (ML) techniques to the field of survival analysis has increased the flexibility of modeling approaches, and ML based models have become state-of-the-art. These models optimize their own cost functions, and their performance is often evaluated using the concordance index (C-index). From a statistical learning perspective, it is therefore an important problem to analyze the relationship between the optimizers of the C-index and those of the ML cost functions. We address this issue by providing C-index Fisher-consistency results and excess risk bounds for several of the commonly used cost functions in survival analysis. We identify conditions under which they are consistent, under the form of three nested families of survival models. We also study the general case where no model assumption is made and present a new, off-the-shelf method that is shown to be consistent with the C-index, although computationally expensive at inference. Finally, we perform limited numerical experiments with simulated data to illustrate our theoretical findings.

Conditional independence testing via weighted partial copulas

This paper introduces the \textit{weighted partial copula} function for testing conditional independence. The proposed test procedure results from these two ingredients: (i) the test statistic is an explicit Cramer-von Mises transformation of the \textit{weighted partial copula}, (ii) the regions of rejection are computed using a bootstrap procedure which mimics conditional independence by generating samples from the product measure of the estimated conditional marginals. Under conditional independence, the weak convergence of the \textit{weighted partial copula proces}s is established when the marginals are estimated using a smoothed local linear estimator. Finally, an experimental section demonstrates that the proposed test has competitive power compared to recent state-of-the-art methods such as kernel-based test.