Robust Calibration of Large Vision-Language Adapters

This paper addresses the critical issue of miscalibration in CLIP-based model adaptation, particularly in the challenging scenario of out-of-distribution (OOD) samples, which has been overlooked in the existing literature on CLIP adaptation. We empirically demonstrate that popular CLIP adaptation approaches, such as Adapters, Prompt Learning, and Test-Time Adaptation, substantially degrade the calibration capabilities of the zero-shot baseline in the presence of distributional drift. We identify the increase in logit ranges as the underlying cause of miscalibration of CLIP adaptation methods, contrasting with previous work on calibrating fully-supervised models. Motivated by these observations, we present a simple and model-agnostic solution to mitigate miscalibration, by scaling the logit range of each sample to its zero-shot prediction logits. We explore three different alternatives to achieve this, which can be either integrated during adaptation or directly used at inference time. Comprehensive experiments on popular OOD classification benchmarks demonstrate the effectiveness of the proposed approaches in mitigating miscalibration while maintaining discriminative performance, whose improvements are consistent across the three families of these increasingly popular approaches. The code is publicly available at: https://github.com/Bala93/CLIPCalib

Class and Region-Adaptive Constraints for Network Calibration

In this work, we present a novel approach to calibrate segmentation networks that considers the inherent challenges posed by different categories and object regions. In particular, we present a formulation that integrates class and region-wise constraints into the learning objective, with multiple penalty weights to account for class and region differences. Finding the optimal penalty weights manually, however, might be unfeasible, and potentially hinder the optimization process. To overcome this limitation, we propose an approach based on Class and Region-Adaptive constraints (CRaC), which allows to learn the class and region-wise penalty weights during training. CRaC is based on a general Augmented Lagrangian method, a well-established technique in constrained optimization. Experimental results on two popular segmentation benchmarks, and two well-known segmentation networks, demonstrate the superiority of CRaC compared to existing approaches. The code is available at: https://github.com/Bala93/CRac/

Exploring the Transferability of a Foundation Model for Fundus Images: Application to Hypertensive Retinopathy

Using deep learning models pre-trained on Imagenet is the traditional solution for medical image classification to deal with data scarcity. Nevertheless, relevant literature supports that this strategy may offer limited gains due to the high dissimilarity between domains. Currently, the paradigm of adapting domain-specialized foundation models is proving to be a promising alternative. However, how to perform such knowledge transfer, and the benefits and limitations it presents, are under study. The CGI-HRDC challenge for Hypertensive Retinopathy diagnosis on fundus images introduces an appealing opportunity to evaluate the transferability of a recently released vision-language foundation model of the retina, FLAIR. In this work, we explore the potential of using FLAIR features as starting point for fundus image classification, and we compare its performance with regard to Imagenet initialization on two popular transfer learning methods: Linear Probing (LP) and Fine-Tuning (FP). Our empirical observations suggest that, in any case, the use of the traditional strategy provides performance gains. In contrast, direct transferability from FLAIR model allows gains of 2.5%. When fine-tuning the whole network, the performance gap increases up to 4%. In this case, we show that avoiding feature deterioration via LP initialization of the classifier allows the best re-use of the rich pre-trained features. Although direct transferability using LP still offers limited performance, we believe that foundation models such as FLAIR will drive the evolution of deep-learning-based fundus image analysis.

A Closer Look at the Few-Shot Adaptation of Large Vision-Language Models

Efficient transfer learning (ETL) is receiving increasing attention to adapt large pre-trained language-vision models on downstream tasks with a few labeled samples. While significant progress has been made, we reveal that state-of-the-art ETL approaches exhibit strong performance only in narrowly-defined experimental setups, and with a careful adjustment of hyperparameters based on a large corpus of labeled samples. In particular, we make two interesting, and surprising empirical observations. First, to outperform a simple Linear Probing baseline, these methods require to optimize their hyper-parameters on each target task. And second, they typically underperform -- sometimes dramatically -- standard zero-shot predictions in the presence of distributional drifts. Motivated by the unrealistic assumptions made in the existing literature, i.e., access to a large validation set and case-specific grid-search for optimal hyperparameters, we propose a novel approach that meets the requirements of real-world scenarios. More concretely, we introduce a CLass-Adaptive linear Probe (CLAP) objective, whose balancing term is optimized via an adaptation of the general Augmented Lagrangian method tailored to this context. We comprehensively evaluate CLAP on a broad span of datasets and scenarios, demonstrating that it consistently outperforms SoTA approaches, while yet being a much more efficient alternative.

A Foundation LAnguage-Image model of the Retina : Encoding expert knowledge in text supervision

Foundation vision-language models are currently transforming computer vision, and are on the rise in medical imaging fueled by their very promising generalization capabilities. However, the initial attempts to transfer this new paradigm to medical imaging have shown less impressive performances than those observed in other domains, due to the significant domain shift and the complex, expert domain knowledge inherent to medical-imaging tasks. Motivated by the need for domain-expert foundation models, we present FLAIR, a pre-trained vision-language model for universal retinal fundus image understanding. To this end, we compiled 37 open-access, mostly categorical fundus imaging datasets from various sources, with up to 97 different target conditions and 284,660 images. We integrate the expert's domain knowledge in the form of descriptive textual prompts, during both pre-training and zero-shot inference, enhancing the less-informative categorical supervision of the data. Such a textual expert's knowledge, which we compiled from the relevant clinical literature and community standards, describes the fine-grained features of the pathologies as well as the hierarchies and dependencies between them. We report comprehensive evaluations, which illustrate the benefit of integrating expert knowledge and the strong generalization capabilities of FLAIR under difficult scenarios with domain shifts or unseen categories. When adapted with a lightweight linear probe, FLAIR outperforms fully-trained, dataset-focused models, more so in the few-shot regimes. Interestingly, FLAIR outperforms by a large margin more generalist, larger-scale image-language models, which emphasizes the potential of embedding experts' domain knowledge and the limitations of generalist models in medical imaging.