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John Freymann

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The Brain Tumor Segmentation (BraTS) Challenge 2023: Brain MR Image Synthesis for Tumor Segmentation (BraSyn)

May 20, 2023
Hongwei Bran Li, Syed Muhammad Anwar, Gian Marco Conte, Florian Kofler, Koen van Leemput, Marie Piraud, Ivan Ezhov, Felix Meissen, Maruf Adewole, Anastasia Janas, Anahita Fathi Kazerooni, Dominic LaBella, Ahmed W. Moawad, Keyvan Farahani, James Eddy, Timothy Bergquist, Verena Chung, Russell Takeshi Shinohara, Farouk Dako, Walter Wiggins, Zachary Reitman, Chunhao Wang, Xinyang Liu, Zhifan Jiang, Ariana Familiar, Elaine Johanson, Zeke Meier, Christos Davatzikos, John Freymann, Justin Kirby, Michel Bilello, Hassan M. Fathallah-Shaykh, Roland Wiest, Jan Kirschke, Rivka R. Colen, Aikaterini Kotrotsou, Pamela Lamontagne, Daniel Marcus, Mikhail Milchenko, Arash Nazeri, Marc André Weber, Abhishek Mahajan, Suyash Mohan, John Mongan, Christopher Hess, Soonmee Cha, Javier Villanueva, Meyer Errol Colak, Priscila Crivellaro, Andras Jakab, Jake Albrecht, Udunna Anazodo, Mariam Aboian, Thomas Yu, Verena Chung, Timothy Bergquist, James Eddy, Jake Albrecht, Ujjwal Baid, Spyridon Bakas, Marius George Linguraru, Bjoern Menze, Juan Eugenio Iglesias, Benedikt Wiestler

Figure 1 for The Brain Tumor Segmentation (BraTS) Challenge 2023: Brain MR Image Synthesis for Tumor Segmentation (BraSyn)

Automated brain tumor segmentation methods are well established, reaching performance levels with clear clinical utility. Most algorithms require four input magnetic resonance imaging (MRI) modalities, typically T1-weighted images with and without contrast enhancement, T2-weighted images, and FLAIR images. However, some of these sequences are often missing in clinical practice, e.g., because of time constraints and/or image artifacts (such as patient motion). Therefore, substituting missing modalities to recover segmentation performance in these scenarios is highly desirable and necessary for the more widespread adoption of such algorithms in clinical routine. In this work, we report the set-up of the Brain MR Image Synthesis Benchmark (BraSyn), organized in conjunction with the Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2023. The objective of the challenge is to benchmark image synthesis methods that realistically synthesize missing MRI modalities given multiple available images to facilitate automated brain tumor segmentation pipelines. The image dataset is multi-modal and diverse, created in collaboration with various hospitals and research institutions.

* Technical report of BraSyn 
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The Brain Tumor Segmentation (BraTS) Challenge 2023: Local Synthesis of Healthy Brain Tissue via Inpainting

May 15, 2023
Florian Kofler, Felix Meissen, Felix Steinbauer, Robert Graf, Eva Oswald, Ezequiel de da Rosa, Hongwei Bran Li, Ujjwal Baid, Florian Hoelzl, Oezguen Turgut, Izabela Horvath, Diana Waldmannstetter, Christina Bukas, Maruf Adewole, Syed Muhammad Anwar, Anastasia Janas, Anahita Fathi Kazerooni, Dominic LaBella, Ahmed W Moawad, Keyvan Farahani, James Eddy, Timothy Bergquist, Verena Chung, Russell Takeshi Shinohara, Farouk Dako, Walter Wiggins, Zachary Reitman, Chunhao Wang, Xinyang Liu, Zhifan Jiang, Ariana Familiar, Gian-Marco Conte, Elaine Johanson, Zeke Meier, Christos Davatzikos, John Freymann, Justin Kirby, Michel Bilello, Hassan M Fathallah-Shaykh, Roland Wiest, Jan Kirschke, Rivka R Colen, Aikaterini Kotrotsou, Pamela Lamontagne, Daniel Marcus, Mikhail Milchenko, Arash Nazeri, Marc-André Weber, Abhishek Mahajan, Suyash Mohan, John Mongan, Christopher Hess, Soonmee Cha, Javier Villanueva-Meyer, Errol Colak, Priscila Crivellaro, Andras Jakab, Jake Albrecht, Udunna Anazodo, Mariam Aboian, Juan Eugenio Iglesias, Koen Van Leemput, Spyridon Bakas, Daniel Rueckert, Benedikt Wiestler, Ivan Ezhov, Marie Piraud, Bjoern Menze

Figure 1 for The Brain Tumor Segmentation (BraTS) Challenge 2023: Local Synthesis of Healthy Brain Tissue via Inpainting

A myriad of algorithms for the automatic analysis of brain MR images is available to support clinicians in their decision-making. For brain tumor patients, the image acquisition time series typically starts with a scan that is already pathological. This poses problems, as many algorithms are designed to analyze healthy brains and provide no guarantees for images featuring lesions. Examples include but are not limited to algorithms for brain anatomy parcellation, tissue segmentation, and brain extraction. To solve this dilemma, we introduce the BraTS 2023 inpainting challenge. Here, the participants' task is to explore inpainting techniques to synthesize healthy brain scans from lesioned ones. The following manuscript contains the task formulation, dataset, and submission procedure. Later it will be updated to summarize the findings of the challenge. The challenge is organized as part of the BraTS 2023 challenge hosted at the MICCAI 2023 conference in Vancouver, Canada.

* 5 pages, 1 figure 
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QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation -- Analysis of Ranking Metrics and Benchmarking Results

Dec 19, 2021
Raghav Mehta, Angelos Filos, Ujjwal Baid, Chiharu Sako, Richard McKinley, Michael Rebsamen, Katrin Dätwyler, Raphael Meier, Piotr Radojewski, Gowtham Krishnan Murugesan, Sahil Nalawade, Chandan Ganesh, Ben Wagner, Fang F. Yu, Baowei Fei, Ananth J. Madhuranthakam, Joseph A. Maldjian, Laura Daza, Catalina Gómez, Pablo Arbeláez, Chengliang Dai, Shuo Wang, Hadrien Raynaud, Yuanhan Mo, Elsa Angelini, Yike Guo, Wenjia Bai, Subhashis Banerjee, Linmin Pei, Murat AK, Sarahi Rosas-González, Illyess Zemmoura, Clovis Tauber, Minh H. Vu, Tufve Nyholm, Tommy Löfstedt, Laura Mora Ballestar, Veronica Vilaplana, Hugh McHugh, Gonzalo Maso Talou, Alan Wang, Jay Patel, Ken Chang, Katharina Hoebel, Mishka Gidwani, Nishanth Arun, Sharut Gupta, Mehak Aggarwal, Praveer Singh, Elizabeth R. Gerstner, Jayashree Kalpathy-Cramer, Nicolas Boutry, Alexis Huard, Lasitha Vidyaratne, Md Monibor Rahman, Khan M. Iftekharuddin, Joseph Chazalon, Elodie Puybareau, Guillaume Tochon, Jun Ma, Mariano Cabezas, Xavier Llado, Arnau Oliver, Liliana Valencia, Sergi Valverde, Mehdi Amian, Mohammadreza Soltaninejad, Andriy Myronenko, Ali Hatamizadeh, Xue Feng, Quan Dou, Nicholas Tustison, Craig Meyer, Nisarg A. Shah, Sanjay Talbar, Marc-Andr Weber, Abhishek Mahajan, Andras Jakab, Roland Wiest, Hassan M. Fathallah-Shaykh, Arash Nazeri, Mikhail Milchenko, Daniel Marcus, Aikaterini Kotrotsou, Rivka Colen, John Freymann, Justin Kirby, Christos Davatzikos, Bjoern Menze, Spyridon Bakas, Yarin Gal, Tal Arbel

Figure 1 for QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation -- Analysis of Ranking Metrics and Benchmarking Results
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Figure 4 for QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation -- Analysis of Ranking Metrics and Benchmarking Results

Deep learning (DL) models have provided the state-of-the-art performance in a wide variety of medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment segmentation (e.g., tumor and lesion sub-regions) is particularly challenging, and potential errors hinder the translation of DL models into clinical workflows. Quantifying the reliability of DL model predictions in the form of uncertainties, could enable clinical review of the most uncertain regions, thereby building trust and paving the way towards clinical translation. Recently, a number of uncertainty estimation methods have been introduced for DL medical image segmentation tasks. Developing metrics to evaluate and compare the performance of uncertainty measures will assist the end-user in making more informed decisions. In this study, we explore and evaluate a metric developed during the BraTS 2019-2020 task on uncertainty quantification (QU-BraTS), and designed to assess and rank uncertainty estimates for brain tumor multi-compartment segmentation. This metric (1) rewards uncertainty estimates that produce high confidence in correct assertions, and those that assign low confidence levels at incorrect assertions, and (2) penalizes uncertainty measures that lead to a higher percentages of under-confident correct assertions. We further benchmark the segmentation uncertainties generated by 14 independent participating teams of QU-BraTS 2020, all of which also participated in the main BraTS segmentation task. Overall, our findings confirm the importance and complementary value that uncertainty estimates provide to segmentation algorithms, and hence highlight the need for uncertainty quantification in medical image analyses. Our evaluation code is made publicly available at https://github.com/RagMeh11/QU-BraTS.

* Under submission at MELBA journal 
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