Heatmap Guided Query Transformers for Robust Astrocyte Detection across Immunostains and Resolutions

Astrocytes are critical glial cells whose altered morphology and density are hallmarks of many neurological disorders. However, their intricate branching and stain dependent variability make automated detection of histological images a highly challenging task. To address these challenges, we propose a hybrid CNN Transformer detector that combines local feature extraction with global contextual reasoning. A heatmap guided query mechanism generates spatially grounded anchors for small and faint astrocytes, while a lightweight Transformer module improves discrimination in dense clusters. Evaluated on ALDH1L1 and GFAP stained astrocyte datasets, the model consistently outperformed Faster R-CNN, YOLOv11 and DETR, achieving higher sensitivity with fewer false positives, as confirmed by FROC analysis. These results highlight the potential of hybrid CNN Transformer architectures for robust astrocyte detection and provide a foundation for advanced computational pathology tools.

DiM-Gesture: Co-Speech Gesture Generation with Adaptive Layer Normalization Mamba-2 framework

Speech-driven gesture generation is an emerging domain within virtual human creation, where current methods predominantly utilize Transformer-based architectures that necessitate extensive memory and are characterized by slow inference speeds. In response to these limitations, we propose \textit{DiM-Gestures}, a novel end-to-end generative model crafted to create highly personalized 3D full-body gestures solely from raw speech audio, employing Mamba-based architectures. This model integrates a Mamba-based fuzzy feature extractor with a non-autoregressive Adaptive Layer Normalization (AdaLN) Mamba-2 diffusion architecture. The extractor, leveraging a Mamba framework and a WavLM pre-trained model, autonomously derives implicit, continuous fuzzy features, which are then unified into a singular latent feature. This feature is processed by the AdaLN Mamba-2, which implements a uniform conditional mechanism across all tokens to robustly model the interplay between the fuzzy features and the resultant gesture sequence. This innovative approach guarantees high fidelity in gesture-speech synchronization while maintaining the naturalness of the gestures. Employing a diffusion model for training and inference, our framework has undergone extensive subjective and objective evaluations on the ZEGGS and BEAT datasets. These assessments substantiate our model's enhanced performance relative to contemporary state-of-the-art methods, demonstrating competitive outcomes with the DiTs architecture (Persona-Gestors) while optimizing memory usage and accelerating inference speed.